The efficacy of topical human amniotic membrane-mesenchymal stem cell-conditioned medium (hAMMSC-CM) and a mixture of topical hAMMSC-CM plus vitamin C and hAMMSC-CM plus vitamin E on chronic plantar ulcers in leprosy:a randomized control trial

被引：28

作者：

Prakoeswa, C. R. S. ^{[1
]}

Natallya, F. R. ^{[1
]}

Harnindya, D. ^{[1
]}

Thohiroh, A. ^{[1
]}

Oktaviyanti, R. N. ^{[1
]}

Pratiwi, K. D. ^{[1
]}

Rubianti, M. A. ^{[1
]}

Yogatri, B. ^{[1
]}

Primasari, P. I. ^{[1
]}

Herwanto, N. ^{[1
]}

Alinda, M. D. ^{[1
]}

Kusumaputra, B. H. ^{[1
]}

Astari, L. ^{[1
]}

Listiawan, M. Y. ^{[1
]}

Agusni, I. ^{[1
]}

Rantam, F. A. ^{[2
,3
]}

机构：

[1] Univ Airlangga, Sch Med, Dr Soetomo Teaching Hosp, Dept Dermatol Venerol, Surabaya, Indonesia

[2] Univ Airlangga, Stem Cell Res & Dev Ctr, Surabaya, Indonesia

[3] Univ Airlangga, Fac Vet Med, Dept Microbiol, Virol & Immunol Lab, Surabaya, Indonesia

来源：

JOURNAL OF DERMATOLOGICAL TREATMENT | 2018年 / 29卷 / 08期

关键词：

hAMMSC-CM; vitamin E; vitamin C; chronic plantar ulcers in leprosy; SKIN;

D O I：

10.1080/09546634.2018.1467541

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Healing of chronic plantar ulcers in leprosy (CPUL) typically takes a long time due to impaired neurological function, thereby reducing the levels of growth factors and cytokines. Cytokines can be found in metabolite products from amniotic membrane stem cells. Chronic ulcers are frequently characterized by high levels of reactive oxygen species. Vitamin E (alpha-tocopherol) is widely used in skin lesions, owing to its antioxidant and anti-inflammatory properties. Vitamin C also has antioxidant, anti-inflammatory, and collagen synthesis properties which are useful in wound healing. Herein, we compared the effects of topical human amniotic membrane-mesenchymal stem cell-conditioned medium (hAMMSC-CM) alone and with vitamins C and E on healing of CPUL. Methods: In this randomized controlled trial, topical agents were applied every 3 days for up to 8 weeks. Ulcer size, side-effects, and possible complications were monitored weekly. Results: Healing percentage increased each week in all groups. Mean difference in ulcer size was highest in the hAMMSC-CM + vitamin E group, implying better progress of wound healing. There were no side-effects or complications. Conclusions: hAMMSC-CM + vitamin E is best for healing of CPUL.

引用

页码：835 / 840

页数：6

共 28 条

[1]

[Anonymous], 2015, J BIOMED SCI ENG, DOI DOI 10.4236/JBISE.2015.87039

[2] Clinic-epidemiological evaluation of ulcers in patients with leprosy sequelae and the effect of low level laser therapy on wound healing: a randomized clinical trial [J].