Type II transmembrane serine proteases

被引：92

作者：

Szabo, R

Wu, QY

Dickson, RB

Netzel-Arnett, S

Antalis, TM

Bugge, TH

机构：

[1] Natl Inst Dent & Craniofacial Res, Proteases & Tissue Remodeling Unit, Oral & Pharyngeal Canc Branch, NIH, Bethesda, MD 20892 USA

[2] Berlex Biosci, Richmond, CA USA

[3] Georgetown Univ, Med Ctr, Vincent T Lombardi Canc Res Ctr, Washington, DC 20007 USA

[4] Amer Red Cross, Jerome H Holland Lab Biomed Sci, Vasc Biol Dept, Rockville, MD USA

来源：

THROMBOSIS AND HAEMOSTASIS | 2003年 / 90卷 / 02期

关键词：

serine proteases; cell surface proteolysis; transmembrane;

D O I：

10.1160/TH03-02-0071

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The recent availability of human and mouse genome sequences and expressed sequence tag databases facilitated the identification of a large new family of membrane anchored serine proteases, the type II transmembrane serine proteases or TTSPs. Analyses of human inherited disorders and gene targeting studies in mice have revealed that several members of this new protease family have critical functions in development and health. Preliminary studies also suggest that aberrant expression of type II transmembrane serine proteases may be linked to disease progression. The knowledge gathered thus far of the genetics, physiology, and pathology of this interesting new serine protease family will be reviewed here in brief.

引用

页码：185 / 193

页数：9

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