A reusable magnetic nickel nanoparticle based catalyst for the aqueous synthesis of diverse heterocycles and their evaluation as potential anti-bacterial agent

被引：33

作者：

Bhattacharjee, Deboshikha ^{[1
]}

Sheet, Sanjoy Kumar ^{[1
]}

Khatua, Snehadrinarayan ^{[1
]}

Biswas, Koel ^{[2
]}

Joshi, Santaram ^{[2
]}

Myrboh, Bekington ^{[1
]}

机构：

[1] North Eastern Hill Univ, Dept Chem, Ctr Adv Studies Chem, Mawlai 793022, Shillong, India

[2] North Eastern Hill Univ, Dept Biotechnol & Bioinformat, Microbiol Lab, Shillong 793022, Meghalaya, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2018年 / 26卷 / 18期

关键词：

ONE-POT; XANTHENE DERIVATIVES; EFFICIENT SYNTHESIS; ORGANIC-SYNTHESIS; NI-NANOPARTICLES; L-PROLINE; INHIBITORS; GREEN; WATER; BISCOUMARIN;

D O I：

10.1016/j.bmc.2018.08.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A library of biologically important heterocycles, viz. pyrazolyl pyrimidine-triones, bis(heterocyclyl) methanes were successfully synthesised by the condensation of barbituric acid, pyrazolone with an aldehyde and dimedone/4-hydoxy coumarin with various substituted aldehydes in aqueous medium at room temperature catalysed by nickel nanoparticles which proved to be an efficient magnetically recyclable catalyst. The method is simple, eco-friendly and gave excellent yields of the products without taking recourse to column chromatographic separation procedures. Computational method was employed to elucidate the selective formation of uncyclised product in reaction course. The biological activity of the synthesized compounds were investigated and the results demonstrated profound antibacterial activity.

引用

页码：5018 / 5028

页数：11

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