A prospective study of dietary polyunsaturated fatty acids intake and lung cancer risk

被引:33
作者
Luu, Hung. N. [1 ,2 ,3 ]
Cai, Hui [1 ]
Murff, Harvey J. [1 ,4 ]
Xiang, Yong-Bing [5 ]
Cai, Qiuyin [1 ]
Li, Honglan [5 ]
Gao, Jing [5 ]
Yang, Gong [1 ]
Lan, Qing [6 ]
Gao, Yu-Tang [5 ]
Zheng, Wei [1 ]
Shu, Xiao-Ou [1 ]
机构
[1] Vanderbilt Univ, Sch Med, Div Epidemiol, Dept Med,Vanderbilt Epidemiol Ctr,Vanderbilt Ingr, Nashville, TN 37212 USA
[2] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA
[3] Univ Pittsburgh, Div Canc Control & Populat Sci, Hillman Canc Ctr, UPMC Canc Pavil,5150 Ctr Ave,Suit 4C,Room 466, Pittsburgh, PA 15232 USA
[4] Vet Affairs Med Ctr, Tennessee Valley Healthcare Syst, Nashville, TN 37212 USA
[5] Shanghai Jiao Tong Univ, Dept Epidemiol, Shanghai Canc Inst, Renji Hosp,Sch Med, Shanghai, Peoples R China
[6] NCI, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
基金
美国国家卫生研究院;
关键词
polyunsaturated fatty acids; lung cancer risk; FOOD-FREQUENCY QUESTIONNAIRE; PROLIFERATOR-ACTIVATED RECEPTORS; COLORECTAL-CANCER; CHAIN; OMEGA-3-FATTY-ACIDS; GROWTH; FISH; REPRODUCIBILITY; ADENOCARCINOMA; PREVENTION;
D O I
10.1002/ijc.31608
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Animal studies have shown that polyunsaturated fatty acids (PUFAs) have antineoplastic and anti-inflammatory properties. Results from epidemiologic studies on specific types of PUFAs for lung cancer risk, however, are inconclusive. We prospectively evaluated the association of specific types of dietary PUFA intakes and lung cancer risk in two population-based cohort studies, the Shanghai Women's Health Study (SWHS) and Shanghai Men's Health Study (SMHS) with a total of 121,970 study participants (i.e., 65,076 women and 56,894 men). Dietary fatty acid intakes were derived from data collected at the baseline using validated food frequency questionnaires (FFQs). Cox proportional hazards model was performed to assess the association between PUFAs and lung cancer risk. Total, saturated and monounsaturated fatty acid intakes were not significantly associated with lung cancer risk. Total PUFAs intake was inversely associated with lung cancer risk [HRs and respective 95% CIs for quintiles 2-5 vs quintile 1: 0.84 (0.71-0.98), 0.97 (0.83-1.13), 0.86 (0.74-1.01) and 0.85 (0.73-1.00), p(trend) = 0.11]. However, DHA intake was positively associated with lung cancer risk [HRs and 95% CIs: 1.01 (0.86-1.19), 1.20 (1.03-1.41), 1.21 (1.03-1.42) and 1.24 (1.05-1.47), p(trend) = 0.001]. The ratio of n-6 PUFAs to n-3 PUFAs (i.e., 7:1) was inversely associated with lung cancer risk, particularly among never-smokers and adenocarcinoma patients. Total PUFAs and the ratio between n-6 PUFAs and n-3 PUFAs were inversely associated with lung cancer risk. This study highlights an important public health impact of PUFA intakes toward intervention/prevention programs of lung cancer.
引用
收藏
页码:2225 / 2237
页数:13
相关论文
共 51 条
[1]   Dietary PUFA and cancer [J].
Abel, S. ;
Riedel, S. ;
Gelderblom, W. C. A. .
PROCEEDINGS OF THE NUTRITION SOCIETY, 2014, 73 (03) :361-367
[2]  
American Cancer Society, 2016, CANC FACTS FIG 2016, P72
[3]   Current evidence linking polyunsaturated fatty acids with cancer risk and progression [J].
Azrad, Maria ;
Turgeon, Chelsea ;
Demark-Wahnefried, Wendy .
FRONTIERS IN ONCOLOGY, 2013, 3
[4]   Diet, cancer, and the lipidome [J].
Bougnoux, P ;
Giraudeau, B ;
Couet, C .
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2006, 15 (03) :416-421
[5]   Associations of long-chain ω-3 fatty acids and fish intake with endometrial cancer risk in the VITamins And Lifestyle cohort1-3 [J].
Brasky, Theodore M. ;
Neuhouser, Marian L. ;
Cohn, David E. ;
White, Emily .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2014, 99 (03) :599-608
[6]   Plasma Phospholipid Fatty Acids and Prostate Cancer Risk in the SELECT Trial [J].
Brasky, Theodore M. ;
Darke, Amy K. ;
Song, Xiaoling ;
Tangen, Catherine M. ;
Goodman, Phyllis J. ;
Thompson, Ian M. ;
Meyskens, Frank L., Jr. ;
Goodman, Gary E. ;
Minasian, Lori M. ;
Parnes, Howard L. ;
Klein, Eric A. ;
Kristal, Alan R. .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2013, 105 (15) :1132-1141
[7]   Serum Phospholipid Fatty Acids and Prostate Cancer Risk: Results From the Prostate Cancer Prevention Trial [J].
Brasky, Theodore M. ;
Till, Cathee ;
White, Emily ;
Neuhouser, Marian L. ;
Song, Xiaoling ;
Goodman, Phyllis ;
Thompson, Ian M. ;
King, Irena B. ;
Albanes, Demetrius ;
Kristal, Alan R. .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2011, 173 (12) :1429-1439
[8]   Genetics of lung-cancer susceptibility [J].
Brennan, Paul ;
Hainaut, Pierre ;
Boffetta, Paolo .
LANCET ONCOLOGY, 2011, 12 (04) :399-408
[9]   Dietary patterns and their correlates among middle-aged and elderly Chinese men: a report from the Shanghai Men's Health Study [J].
Cai, Hui ;
Zheng, Wei ;
Xiang, Yong-Bing ;
Xu, Wang Hong ;
Yang, Gong ;
Li, Honglan ;
Shu, Xiao Ou .
BRITISH JOURNAL OF NUTRITION, 2007, 98 (05) :1006-1013
[10]   Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology? [J].
Calder, Philip C. .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2013, 75 (03) :645-662