Reduced γ-aminobutyric acid in the superior temporal gyrus is associated with absolute pitch

被引：3

作者：

Maeshima, Hiroaki ^{[1
]}

Hosoda, Chihiro ^{[1
,3
]}

Okanoya, Kazuo ^{[1
,2
]}

Nakai, Tomoya ^{[1
,4
,5
]}

机构：

[1] Univ Tokyo, Grad Sch Arts & Sci, Tokyo, Japan

[2] Univ Tokyo, Ctr Evolutionary Cognit Sci, Tokyo, Japan

[3] Japan Sci & Technol Agcy, PRESTO, Tokyo, Japan

[4] Natl Inst Informat & Commun Technol, Ctr Informat & Neural Networks, 1-4 Yamadaoka, Suita, Osaka 5650871, Japan

[5] Osaka Univ, Osaka, Japan

来源：

NEUROREPORT | 2018年 / 29卷 / 17期

关键词：

absolute pitch; gamma-aminobutyric acid; magnetic resonance spectroscopy; superior temporal gyrus; GABA CONCENTRATION; CORTEX; CONNECTIVITY; FREQUENCY; MUSICIANS;

D O I：

10.1097/WNR.0000000000001137

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Absolute pitch (AP) is the ability to label the pitch of tones without any reference tones. Previous studies have shown that the anatomical and functional basis of AP exists in the superior temporal gyrus (STG), although the associated neurotransmitters remain unknown. We used proton magnetic resonance spectroscopy to quantify the concentration of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, in the bilateral STG of adult AP possessor and non-AP possessors. We found a significant negative correlation between AP scores and GABA concentration in the left STG. Furthermore, mean GABA concentration was significantly reduced in the AP possessors group compared to the non-AP possessors group. Our results suggest that less inhibition in the bilateral STG may enable AP possessors to associate categorical labels with tones. Copyright (C) 2018 Wolters Kluwer Health, Inc. All rights reserved.

引用

页码：1487 / 1491

页数：5

共 20 条

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