Unbalance Between Sarcoplasmic Reticulum Ca2+ Uptake and Release: A First Step Toward Ca2+ Triggered Arrhythmias and Cardiac Damage

被引：18

作者：

Federico, Marilen ^{[1
]}

Valverde, Carlos A. ^{[1
]}

Mattiazzi, Alicia ^{[1
]}

Palomeque, Julieta ^{[1
,2
]}

机构：

[1] Natl Univ La Plata, CONICET, Ctr Invest Cardiovasc Dr Horacio E Cingolani, CCT La Plata,Fac Cs Med, La Plata, Argentina

[2] Univ Abierta Interamer, Ctr Altos Estudios Ciencias Humanas & Salud, Buenos Aires, DF, Argentina

来源：

FRONTIERS IN PHYSIOLOGY | 2020年 / 10卷

关键词：

sarcoplasmic reticulum Ca2+-ATPase; ryanodine receptor 2; arrhythimas; phospholamban; apoptosis; diabetic myocardiopathy; isquemia-reperfusion; RYANODINE RECEPTOR PHOSPHORYLATION; PROTEIN-KINASE-II; MITOCHONDRIAL PERMEABILITY TRANSITION; BETA-ADRENERGIC STIMULATION; AFFECT CALCIUM SPARKS; INTRACELLULAR CA2+; HEART-FAILURE; PHOSPHOLAMBAN PHOSPHORYLATION; PKA PHOSPHORYLATION; INHIBITION PROTECTS;

D O I：

10.3389/fphys.2019.01630

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The present review focusses on the regulation and interplay of cardiac SR Ca2+ handling proteins involved in SR Ca2+ uptake and release, i.e., SERCa2/PLN and RyR2. Both RyR2 and SERCA2a/PLN are highly regulated by post-translational modifications and/or different partners' proteins. These control mechanisms guarantee a precise equilibrium between SR Ca2+ reuptake and release. The review then discusses how disruption of this balance alters SR Ca2+ handling and may constitute a first step toward cardiac damage and malignant arrhythmias. In the last part of the review, this concept is exemplified in different cardiac diseases, like prediabetic and diabetic cardiomyopathy, digitalis intoxication and ischemia-reperfusion injury.

引用

页数：22

共 50 条

[1] Spectroscopic determination of sarcoplasmic reticulum Ca2+ uptake and Ca2+ release
Gilchrist, JSC
Palahniuk, C
Bose, R
MOLECULAR AND CELLULAR BIOCHEMISTRY, 1997, 172 (1-2) : 159 - 170
[2] Spectroscopic determination of sarcoplasmic reticulum Ca2+ uptake and Ca2+ release
James S.C. Gilchrist
Chris Palahniuk
Ratna Bose
Molecular and Cellular Biochemistry, 1997, 172 : 159 - 170
[3] EFFECTS OF ALKALINE PH ON SARCOPLASMIC-RETICULUM CA2+ RELEASE AND CA2+ UPTAKE
DETTBARN, C
PALADE, P
JOURNAL OF BIOLOGICAL CHEMISTRY, 1991, 266 (14) : 8993 - 9001
[4] Ruthenium red reduces the Ca2+ sensitivity of Ca2+ uptake into cardiac sarcoplasmic reticulum
G. J. Kargacin
Z. Ali
M. E. Kargacin
Pflügers Archiv, 1998, 436 : 338 - 342
[5] Ruthenium red reduces the Ca2+ sensitivity of Ca2+ uptake into cardiac sarcoplasmic reticulum
Kargacin, GJ
Ali, Z
Kargacin, ME
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1998, 436 (03): : 338 - 342
[6] Sarcoplasmic reticulum Ca2+ release flux underlying Ca2+ sparks in cardiac muscle
Proc Natl Acad Sci USA, 8 (4176):
[7] Sarcoplasmic reticulum Ca2+ release flux underlying Ca2+ sparks in cardiac muscle
Blatter, LA
Huser, J
Rios, E
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (08) : 4176 - 4181
[8] Regulation of cardiac muscle Ca2+ release channel by sarcoplasmic reticulum lumenal Ca2+
Xu, L
Meissner, G
BIOPHYSICAL JOURNAL, 1998, 75 (05) : 2302 - 2312
[9] Sarcoplasmic reticulum Ca2+ release in feline ventricular myocytes is triggered by Ca2+ influx not by depolarization
Piacentino, V
Houser, SR
CIRCULATION, 1999, 100 (18) : 629 - 629
[10] Fluorescence probe study of the lumenal Ca2+ of the sarcoplasmic reticulum vesicles during Ca2+ uptake and Ca2+ release
Saiki, Y
Ikemoto, N
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 241 (01) : 181 - 186

← 1 2 3 4 5 →