Replication Study for the Association Between Four Loci Identified by a Genome-Wide Association Study on European American Subjects With Type 1 Diabetes and Susceptibility to Diabetic Nephropathy in Japanese Subjects With Type 2 Diabetes

被引：45

作者：

Maeda, Shiro ^{[1
,2
]}

Araki, Shin-ichi ^{[3
]}

Babazono, Tetsuya ^{[4
]}

Toyoda, Masao ^{[5
]}

Umezono, Tomoya ^{[5
]}

Kawai, Koichi ^{[6
]}

Imanishi, Masahito ^{[7
]}

Uzu, Takashi ^{[3
]}

Watada, Hirotaka ^{[2
,8
]}

Suzuki, Daisuke ^{[5
]}

Kashiwagi, Atsunori ^{[3
]}

Iwamoto, Yasuhiko ^{[4
]}

Kaku, Kohei ^{[9
]}

Kawamori, Ryuzo ^{[2
,8
]}

Nakamura, Yusuke ^{[10
]}

机构：

[1] RIKEN, Ctr Genom Med, Lab Endocrinol & Metab, Yokohama, Kanagawa, Japan

[2] Juntendo Univ, Grad Sch Med, Sportol Ctr, Tokyo, Japan

[3] Shiga Univ Med Sci, Dept Med, Otsu, Shiga 52021, Japan

[4] Tokyo Womens Med Univ, Ctr Diabet, Tokyo, Japan

[5] Tokai Univ, Sch Med, Dept Internal Med, Div Nephrol & Metab, Isehara, Kanagawa 25911, Japan

[6] Kawai Clin, Tsukuba, Ibaraki, Japan

[7] Osaka City Gen Hosp, Div Nephrol & Hypertens, Dept Internal Med, Osaka, Japan

[8] Juntendo Univ, Sch Med, Dept Med Metab & Endocrinol, Tokyo 113, Japan

[9] Kawasaki Med Sch, Dept Internal Med, Div Endocrinol & Metab, Kurashiki, Okayama, Japan

[10] Univ Tokyo, Inst Med Sci, Mol Med Lab, Ctr Human Genome, Tokyo, Japan

来源：

DIABETES | 2010年 / 59卷 / 08期

关键词：

GENETIC-VARIATIONS; VARIANTS; DISEASE; KCNQ1;

D O I：

10.2337/db10-0067

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE-Genetic factors are believed to contribute to the development and progression of diabetic nephropathy. Recently, a genome-wide association study for diabetic nephropathy revealed four novel candidate loci in European American subjects with type 1 diabetes. In this study, we determined the association of the four loci with diabetic nephropathy in Japanese subjects with type 2 diabetes. RESEARCH DESIGN AND METHODS-We genotyped 11 single-nucleotide polymorphisms (SNPs) in four distinct loci (rs39059 and rs39075 in the CPVL/CHN2, rs1888747 and rs10868025 in FRMD3, rs739401 and rs451041 in CARS, and rs1041466, rs1411766, rs6492208, rs7989848, and rs9521445 in a chromosome 13q locus) in four independent Japanese populations RESULTS-Six SNPs were nominally associated with diabetic nephropathy in one of the four Japanese populations (P < 0 05, rs451041 in study 1, rs39059 and rs1888747 in study 3; rs1411766 in studies 1 and 4; and rs7989848 and rs9521445 in study 4); however, no significant association was observed for any SNP after correction for multiple testing errors in the individual populations. Nevertheless, a meta-analysis performed for the data obtained from all four populations revealed that one SNP (rs1411766) in chromosome 13q was significantly associated with diabetic nephropathy in the Japanese populations (nominal P = 0.004, corrected P = 0.04, odds ratio 1.26 [95% CI = 1 07-1.47]). CONCLUSIONS-Our results suggest that the rs1411766 locus may be commonly involved in conferring susceptibility to diabetic nephropathy among subjects with type 1 or type 2 diabetes across different ethnic groups. Diabetes 59:2075-2079, 2010

引用

页码：2075 / 2079

页数：5

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