Replication Study for the Association Between Four Loci Identified by a Genome-Wide Association Study on European American Subjects With Type 1 Diabetes and Susceptibility to Diabetic Nephropathy in Japanese Subjects With Type 2 Diabetes

被引:48
作者
Maeda, Shiro [1 ,2 ]
Araki, Shin-ichi [3 ]
Babazono, Tetsuya [4 ]
Toyoda, Masao [5 ]
Umezono, Tomoya [5 ]
Kawai, Koichi [6 ]
Imanishi, Masahito [7 ]
Uzu, Takashi [3 ]
Watada, Hirotaka [2 ,8 ]
Suzuki, Daisuke [5 ]
Kashiwagi, Atsunori [3 ]
Iwamoto, Yasuhiko [4 ]
Kaku, Kohei [9 ]
Kawamori, Ryuzo [2 ,8 ]
Nakamura, Yusuke [10 ]
机构
[1] RIKEN, Ctr Genom Med, Lab Endocrinol & Metab, Yokohama, Kanagawa, Japan
[2] Juntendo Univ, Grad Sch Med, Sportol Ctr, Tokyo, Japan
[3] Shiga Univ Med Sci, Dept Med, Otsu, Shiga 52021, Japan
[4] Tokyo Womens Med Univ, Ctr Diabet, Tokyo, Japan
[5] Tokai Univ, Sch Med, Dept Internal Med, Div Nephrol & Metab, Isehara, Kanagawa 25911, Japan
[6] Kawai Clin, Tsukuba, Ibaraki, Japan
[7] Osaka City Gen Hosp, Div Nephrol & Hypertens, Dept Internal Med, Osaka, Japan
[8] Juntendo Univ, Sch Med, Dept Med Metab & Endocrinol, Tokyo 113, Japan
[9] Kawasaki Med Sch, Dept Internal Med, Div Endocrinol & Metab, Kurashiki, Okayama, Japan
[10] Univ Tokyo, Inst Med Sci, Mol Med Lab, Ctr Human Genome, Tokyo, Japan
关键词
GENETIC-VARIATIONS; VARIANTS; DISEASE; KCNQ1;
D O I
10.2337/db10-0067
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE-Genetic factors are believed to contribute to the development and progression of diabetic nephropathy. Recently, a genome-wide association study for diabetic nephropathy revealed four novel candidate loci in European American subjects with type 1 diabetes. In this study, we determined the association of the four loci with diabetic nephropathy in Japanese subjects with type 2 diabetes. RESEARCH DESIGN AND METHODS-We genotyped 11 single-nucleotide polymorphisms (SNPs) in four distinct loci (rs39059 and rs39075 in the CPVL/CHN2, rs1888747 and rs10868025 in FRMD3, rs739401 and rs451041 in CARS, and rs1041466, rs1411766, rs6492208, rs7989848, and rs9521445 in a chromosome 13q locus) in four independent Japanese populations RESULTS-Six SNPs were nominally associated with diabetic nephropathy in one of the four Japanese populations (P < 0 05, rs451041 in study 1, rs39059 and rs1888747 in study 3; rs1411766 in studies 1 and 4; and rs7989848 and rs9521445 in study 4); however, no significant association was observed for any SNP after correction for multiple testing errors in the individual populations. Nevertheless, a meta-analysis performed for the data obtained from all four populations revealed that one SNP (rs1411766) in chromosome 13q was significantly associated with diabetic nephropathy in the Japanese populations (nominal P = 0.004, corrected P = 0.04, odds ratio 1.26 [95% CI = 1 07-1.47]). CONCLUSIONS-Our results suggest that the rs1411766 locus may be commonly involved in conferring susceptibility to diabetic nephropathy among subjects with type 1 or type 2 diabetes across different ethnic groups. Diabetes 59:2075-2079, 2010
引用
收藏
页码:2075 / 2079
页数:5
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[11]   A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population [J].
Nakashima, Mitsuko ;
Chung, Suyoun ;
Takahashi, Atsushi ;
Kamatani, Naoyuki ;
Kawaguchi, Takahisa ;
Tsunoda, Tatsuhiko ;
Hosono, Naoya ;
Kubo, Michiaki ;
Nakamura, Yusuke ;
Zembutsu, Hitoshi .
NATURE GENETICS, 2010, 42 (09) :768-U56
[12]   Genome-wide association study identifies susceptibility loci for IgA nephropathy [J].
Gharavi, Ali G. ;
Kiryluk, Krzysztof ;
Choi, Murim ;
Li, Yifu ;
Hou, Ping ;
Xie, Jingyuan ;
Sanna-Cherchi, Simone ;
Men, Clara J. ;
Julian, Bruce A. ;
Wyatt, Robert J. ;
Novak, Jan ;
He, John C. ;
Wang, Haiyan ;
Lv, Jicheng ;
Zhu, Li ;
Wang, Weiming ;
Wang, Zhaohui ;
Yasuno, Kasuhito ;
Gunel, Murat ;
Mane, Shrikant ;
Umlauf, Sheila ;
Tikhonova, Irina ;
Beerman, Isabel ;
Savoldi, Silvana ;
Magistroni, Riccardo ;
Ghiggeri, Gian Marco ;
Bodria, Monica ;
Lugani, Francesca ;
Ravani, Pietro ;
Ponticelli, Claudio ;
Allegri, Landino ;
Boscutti, Giuliano ;
Frasca, Giovanni ;
Amore, Alessandro ;
Peruzzi, Licia ;
Coppo, Rosanna ;
Izzi, Claudia ;
Viola, Battista Fabio ;
Prati, Elisabetta ;
Salvadori, Maurizio ;
Mignani, Renzo ;
Gesualdo, Loreto ;
Bertinetto, Francesca ;
Mesiano, Paola ;
Amoroso, Antonio ;
Scolari, Francesco ;
Chen, Nan ;
Zhang, Hong ;
Lifton, Richard P. .
NATURE GENETICS, 2011, 43 (04) :321-U68
[13]   Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes [J].
Imamura, Minako ;
Takahashi, Atsushi ;
Yamauchi, Toshimasa ;
Hara, Kazuo ;
Yasuda, Kazuki ;
Grarup, Niels ;
Zhao, Wei ;
Wang, Xu ;
Huerta-Chagoya, Alicia ;
Hu, Cheng ;
Moon, Sanghoon ;
Long, Jirong ;
Kwak, Soo Heon ;
Rasheed, Asif ;
Saxena, Richa ;
Ma, Ronald C. W. ;
Okada, Yukinori ;
Iwata, Minoru ;
Hosoe, Jun ;
Shojima, Nobuhiro ;
Iwasaki, Minaka ;
Fujita, Hayato ;
Suzuki, Ken ;
Danesh, John ;
Jorgensen, Torben ;
Jorgensen, Marit E. ;
Witte, Daniel R. ;
Brandslund, Ivan ;
Christensen, Cramer ;
Hansen, Torben ;
Mercader, Josep M. ;
Flannick, Jason ;
Moreno-Macias, Hortensia ;
Burtt, Noel P. ;
Zhang, Rong ;
Kim, Young Jin ;
Zheng, Wei ;
Singh, Jai Rup ;
Tam, Claudia H. T. ;
Hirose, Hiroshi ;
Maegawa, Hiroshi ;
Ito, Chikako ;
Kaku, Kohei ;
Watada, Hirotaka ;
Tanaka, Yasushi ;
Tobe, Kazuyuki ;
Kawamori, Ryuzo ;
Kubo, Michiaki ;
Cho, Yoon Shin ;
Chan, Juliana C. N. .
NATURE COMMUNICATIONS, 2016, 7
[14]   Evaluation of Genome Wide Association Study Associated Type 2 Diabetes Susceptibility Loci in Sub Saharan Africans [J].
Adeyemo, Adebowale A. ;
Tekola-Ayele, Fasil ;
Doumatey, Ayo P. ;
Bentley, Amy R. ;
Chen, Guanjie ;
Huang, Hanxia ;
Zhou, Jie ;
Shriner, Daniel ;
Fasanmade, Olufemi ;
Okafor, Godfrey ;
Eghan, Benjamin, Jr. ;
Agyenim-Boateng, Kofi ;
Adeleye, Jokotade ;
Balogun, Williams ;
Elkahloun, Abdel ;
Chandrasekharappa, Settara ;
Owusu, Samuel ;
Amoah, Albert ;
Acheampong, Joseph ;
Johnson, Thomas ;
Oli, Johnnie ;
Adebamowo, Clement ;
Collins, Francis ;
Dunston, Georgia ;
Rotimi, Charles N. .
FRONTIERS IN GENETICS, 2015, 6
[15]   Joint Effects of Known Type 2 Diabetes Susceptibility Loci in Genome-Wide Association Study of Singapore Chinese: The Singapore Chinese Health Study [J].
Chen, Zhanghua ;
Pereira, Mark A. ;
Seielstad, Mark ;
Koh, Woon-Puay ;
Tai, E. Shyong ;
Teo, Yik-Ying ;
Liu, Jianjun ;
Hsu, Chris ;
Wang, Renwei ;
Odegaard, Andrew O. ;
Thyagarajan, Bharat ;
Koratkar, Revati ;
Yuan, Jian-Min ;
Gross, Myron D. ;
Stram, Daniel O. .
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[16]   Genome-wide association study identified new susceptibility loci for polycystic ovary syndrome [J].
Lee, Hyejin ;
Oh, Jee-Young ;
Sung, Yeon-Ah ;
Chung, Hyewon ;
Kim, Hyung-Lae ;
Kim, Gwang Sub ;
Cho, Yoon Shin ;
Kim, Jin Taek .
HUMAN REPRODUCTION, 2015, 30 (03) :723-731
[17]   Genome-Wide Association Studies-derived susceptibility loci in Type 2 Diabetes: confirmation in a Chinese population [J].
Lu, Shuangyan ;
Xie, Yan ;
Lin, Kun ;
Li, Siwei ;
Zhou, Yidan ;
Ma, Pei ;
Lv, Zhihua ;
Zhou, Xin .
CLINICAL AND INVESTIGATIVE MEDICINE, 2012, 35 (05) :E327-E333
[18]   Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes [J].
Barrett, Jeffrey C. ;
Clayton, David G. ;
Concannon, Patrick ;
Akolkar, Beena ;
Cooper, Jason D. ;
Erlich, Henry A. ;
Julier, Cecile ;
Morahan, Grant ;
Nerup, Jorn ;
Nierras, Concepcion ;
Plagnol, Vincent ;
Pociot, Flemming ;
Schuilenburg, Helen ;
Smyth, Deborah J. ;
Stevens, Helen ;
Todd, John A. ;
Walker, Neil M. ;
Rich, Stephen S. .
NATURE GENETICS, 2009, 41 (06) :703-707
[19]   12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population [J].
Takata, Ryo ;
Takahashi, Atsushi ;
Fujitat, Masashi ;
Momozawa, Yukihide ;
Saunders, Edward J. ;
Yamada, Hiroki ;
Maejima, Kazuhiro ;
Nakano, Kaoru ;
Nishida, Yuichiro ;
Hishida, Asahi ;
Matsuo, Keitaro ;
Wakai, Kenji ;
Yamaji, Taiki ;
Sawada, Norie ;
Iwasaki, Motoki ;
Tsugane, Shoichiro ;
Sasaki, Makoto ;
Shimizu, Atsushi ;
Tanno, Kozo ;
Minegishi, Naoko ;
Suzuki, Kichiya ;
Matsuda, Koichi ;
Kubo, Michiaki ;
Inazawa, Johji ;
Egawa, Shin ;
Haiman, Christopher A. ;
Ogawa, Osamu ;
Obara, Wataru ;
Kamatani, Yoichiro ;
Akamatsu, Shusuke ;
Nakagawa, Hidewaki .
NATURE COMMUNICATIONS, 2019, 10 (1)
[20]   Genome-wide association study identifies novel type II diabetes risk loci in Jordan subpopulations [J].
Dajani, Rana ;
Li, Jin ;
Wei, Zhi ;
March, Michael E. ;
Xi, Qianghua ;
Khader, Yousef ;
Hakooz, Nancy ;
Fatahallah, Raja ;
El-Khateeb, Mohammed ;
Arafat, Ala ;
Saleh, Tareq ;
Dajani, Abdel Rahman ;
Al-Abbadi, Zaid ;
Qader, Mohamed Abdul ;
Shiyab, Abdel Halim ;
Bateiha, Anwar ;
Ajlouni, Kamel ;
Hakonarson, Hakon .
PEERJ, 2017, 5