Metalation of diazines .17. Very hindered bases as new metalating agents; Improvement of regioselectivity for the metalation of 3-chloro-6-methoxypyridazine

被引:19
|
作者
Mojovic, L [1 ]
Turck, A [1 ]
Ple, N [1 ]
Dorsy, M [1 ]
Ndzi, B [1 ]
Queguiner, G [1 ]
机构
[1] INSA,IRCOF,LAB CHIM ORGAN FINE & HETEROCYCL,CNRS,URA 1429,F-76131 MONT ST AIGNAN,FRANCE
关键词
D O I
10.1016/0040-4020(96)00568-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The different factors governing the regioselectivity of the metalation of 3-chloro-6-methoxypyridazine with alkylamides were studied. Very hindered bases were used as new metalating agents and a very good regioselectivity was obtained. Copyright (C) 1996 Elsevier Science Ltd
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页码:10417 / 10426
页数:10
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