Roxithromycin-induced digoxin toxicity

被引：10

作者：

Corallo, CE

Rogers, IR

机构：

[1] Box Hill Hospital, Box Hill, Vic.

[2] Department of Emergency Medicine, Auckland Hospital

[3] Pharmacy Department, Box Hill Hospital, Box Hill, Vic. 3128, Nelson Road

来源：

MEDICAL JOURNAL OF AUSTRALIA | 1996年 / 165卷 / 08期

关键词：

D O I：

10.5694/j.1326-5377.1996.tb138580.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 76-year-old woman presented with digoxin toxicity four days after starting a course of roxithromycin. In 10%-15% of the population, digoxin is degraded extensively by bacteria in the gastrointestinal tract, and antibiotic-induced changes in the bacterial flora may lead to digoxin toxicity.

引用

收藏

页码：433 / 434

页数：2

相关论文

共 10 条

[1] TREATMENT OF 150 CASES OF LIFE-THREATENING DIGITALIS INTOXICATION WITH DIGOXIN-SPECIFIC FAB ANTIBODY FRAGMENTS - FINAL REPORT OF A MULTICENTER STUDY [J].

ANTMAN, EM ;

WENGER, TL ;

BUTLER, VP ;

HABER, E ;

SMITH, TW .

CIRCULATION, 1990, 81 (06) :1744-1752

[2] CLARITHROMYCIN-INDUCED DIGOXIN TOXICITY IN A PATIENT WITH AIDS [J].

FORD, A ;

SMITH, LC ;

BALTCH, AL ;

SMITH, RP .

CLINICAL INFECTIOUS DISEASES, 1995, 21 (04) :1051-1052

[3]

KRISANDA TJ, 1993, TOP EMERG MED, V15, P41

[4] INACTIVATION OF DIGOXIN BY THE GUT FLORA - REVERSAL BY ANTIBIOTIC-THERAPY [J].

LINDENBAUM, J ;

RUND, DG ;

BUTLER, VP ;

TSEENG, D ;

SAHA, JR .

NEW ENGLAND JOURNAL OF MEDICINE, 1981, 305 (14) :789-794

[5] CARDIAC-GLYCOSIDES - DRUG-INTERACTIONS OF CLINICAL-SIGNIFICANCE [J].

MAGNANI, B ;

MALINI, PL .

DRUG SAFETY, 1995, 12 (02) :97-109

[6] COST-EFFECTIVENESS ANALYSIS OF THE USE OF DIGOXIN IMMUNE FAB(OVINE) FOR TREATMENT OF DIGOXIN TOXICITY [J].

MAUSKOPF, JA ;

WENGER, TL .

AMERICAN JOURNAL OF CARDIOLOGY, 1991, 68 (17) :1709-1714

[7] CLARITHROMYCIN-RELATED TOXIC EFFECTS OF DIGOXIN [J].

MIDONECK, SR ;

ETINGIN, OR .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (22) :1505-1505

[8]

*MIMS AUSTR, 1996, 1996 MIMS ANN, P1345

[9] ERYTHROMYCIN-INDUCED DIGOXIN TOXICITY [J].

MORTON, MR ;

COOPER, JW .

DICP-THE ANNALS OF PHARMACOTHERAPY, 1989, 23 (09) :668-670

[10] PHARMACOKINETIC DRUG-INTERACTIONS OF MACROLIDES [J].

PERITI, P ;

MAZZEI, T ;

MINI, E ;

NOVELLI, A .

CLINICAL PHARMACOKINETICS, 1992, 23 (02) :106-131