Telomere Length Among Older US Adults: Differences by Race/Ethnicity, Gender, and Age

被引：70
作者：
Brown, Lauren [1 ]
Needham, Belinda [2 ]
Ailshire, Jennifer [1 ]
机构：
[1] Univ Southern Calif, Los Angeles, CA 90089 USA
[2] Univ Michigan, Ann Arbor, MI 48109 USA
来源：
JOURNAL OF AGING AND HEALTH | 2017年 / 29卷 / 08期
基金：
美国国家卫生研究院;
关键词：
biomarkers of aging; health disparities; minority aging; accelerated aging; social epidemiology; CARDIOVASCULAR-DISEASE; SOCIOECONOMIC-STATUS; AFRICAN-AMERICANS; HEALTH; ASSOCIATION; BEHAVIOR; OBESITY; STATES;
D O I：
10.1177/0898264316661390
中图分类号：
R4 [临床医学]; R592 [老年病学];
学科分类号：
1002 ; 100203 ; 100602 ;
摘要：
Objective: We examine race/ethnic, gender, and age differences in telomere length (TL) within a diverse, nationally representative sample of older adults. Method: Data come from 5,228 White, Black, and Hispanic respondents aged 54+ in the 2008 Health and Retirement Study. TL was assayed from saliva using quantitative polymerase chain reaction (qPCR) by comparing telomere sequence copy number with a single gene copy number (T/S ratio). Linear regression was used to examine TL by race/ethnicity, gender, and age adjusting for social, economic, and health characteristics. Results: Women had longer TL than men (p < .05). Blacks (p < .05) and Hispanics (p < .10) had longer TL than Whites. Black women and men had the longest TL relative to other groups (p < .05), while White men had the shortest TL (p < .05). Black women and Hispanic men showed greater differences in TL with age. Discussion: Findings indicate social patterns in TL by race/ethnicity, gender, and age among older adults do not reflect differences observed in most population health outcomes.
引用
收藏
页码：1350 / 1366
页数：17
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