A Highly Efficient NHC-Catalyzed Aerobic Oxidation of Aldehydes to Carboxylic Acids

被引：19

作者：

Khatana, Anil Kumar ^{[1
,2
]}

Singh, Vikram ^{[1
]}

Gupta, Manoj Kumar ^{[2
]}

Tiwari, Bhoopendra ^{[1
]}

机构：

[1] Ctr Biomed Res, Div Mol Synth & Drug Discovery, SGPGIMS Campus,Raebareli Rd, Lucknow 226014, Uttar Pradesh, India

[2] Cent Univ Haryana, Dept Chem, Mahendergarh 123031, Haryana, India

来源：

SYNTHESIS-STUTTGART | 2018年 / 50卷 / 21期

关键词：

carboxylic acids; aldehydes; N-heterocyclic carbenes; aerobic oxidation; organocatalysis; N-HETEROCYCLIC CARBENES; AROMATIC-ALDEHYDES; POTASSIUM-PERMANGANATE; SELECTIVE OXIDATION; DOMINO REACTIONS; ALCOHOLS; WATER; ACTIVATION; ORGANOCATALYSIS; TRANSFORMATION;

D O I：

10.1055/s-0037-1610069

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An N-heterocyclic carbene (NHC) organocatalytic aerobic oxidation of aldehydes to the corresponding carboxylic acids is explored. Remarkably, this method allows for efficient conversion of different classes of aldehydes including highly challenging electron-rich aryl aldehydes, ortho -substituted aryl aldehydes, various heteroaromatic aldehydes and ,-unsaturated aldehydes under mild reaction conditions. These substrates, under previously reported NHC-catalyzed methods, are typically unreactive or give poor yields, require high reaction temperatures and reaction times of several days.

引用

页码：4290 / 4294

页数：5

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