Perinatal Hypoxic-Ischemic Encephalopathy

被引：156

作者：

Lai, Ming-Chi ^{[2
]}

Yang, San-Nan ^{[1
,3
,4
,5
]}

机构：

[1] Kaohsiung Med Univ, Grad Inst Med, Kaohsiung 807, Taiwan

[2] Chi Mei Med Ctr, Dept Pediat, Tainan, Taiwan

[3] Kaohsiung Med Univ, Ctr Excellence Environm Med, Kaohsiung 807, Taiwan

[4] Kaohsiung Med Univ Hosp, Dept Pediat, Kaohsiung, Taiwan

[5] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 80424, Taiwan

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2011年

关键词：

EXCITATORY AMINO-ACIDS; MAGNETIC-RESONANCE-SPECTROSCOPY; SECONDARY ENERGY FAILURE; BRAIN-INJURY; NEWBORN PIGLET; RAT-BRAIN; NEURONAL DEATH; SELECTIVE VULNERABILITY; NEONATAL ENCEPHALOPATHY; MITOCHONDRIAL-FUNCTION;

D O I：

10.1155/2011/609813

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Perinatal hypoxic-ischemic encephalopathy (HIE) is an important cause of brain injury in the newborn and can result in long-term devastating consequences. Perinatal hypoxia is a vital cause of long-term neurologic complications varying from mild behavioural deficits to severe seizure, mental retardation, and/or cerebral palsy in the newborn. In the mammalian developing brain, ongoing research into pathophysiological mechanism of neuronal injury and therapeutic strategy after perinatal hypoxia is still limited. With the advent of promising therapy of hypothermia in HIE, this paper reviews the pathophysiology of HIE and the future potential neuroprotective strategies for clinical potential for hypoxia sufferers.

引用

页数：6

共 58 条

[31] DELAYED (SECONDARY) CEREBRAL ENERGY FAILURE AFTER ACUTE HYPOXIA-ISCHEMIA IN THE NEWBORN PIGLET - CONTINUOUS 48-HOUR STUDIES BY PHOSPHORUS MAGNETIC-RESONANCE SPECTROSCOPY [J].