Perinatal Hypoxic-Ischemic Encephalopathy

被引：156
作者：
Lai, Ming-Chi [2 ]
Yang, San-Nan [1 ,3 ,4 ,5 ]
机构：
[1] Kaohsiung Med Univ, Grad Inst Med, Kaohsiung 807, Taiwan
[2] Chi Mei Med Ctr, Dept Pediat, Tainan, Taiwan
[3] Kaohsiung Med Univ, Ctr Excellence Environm Med, Kaohsiung 807, Taiwan
[4] Kaohsiung Med Univ Hosp, Dept Pediat, Kaohsiung, Taiwan
[5] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 80424, Taiwan
来源：
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2011年
关键词：
EXCITATORY AMINO-ACIDS; MAGNETIC-RESONANCE-SPECTROSCOPY; SECONDARY ENERGY FAILURE; BRAIN-INJURY; NEWBORN PIGLET; RAT-BRAIN; NEURONAL DEATH; SELECTIVE VULNERABILITY; NEONATAL ENCEPHALOPATHY; MITOCHONDRIAL-FUNCTION;
D O I：
10.1155/2011/609813
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Perinatal hypoxic-ischemic encephalopathy (HIE) is an important cause of brain injury in the newborn and can result in long-term devastating consequences. Perinatal hypoxia is a vital cause of long-term neurologic complications varying from mild behavioural deficits to severe seizure, mental retardation, and/or cerebral palsy in the newborn. In the mammalian developing brain, ongoing research into pathophysiological mechanism of neuronal injury and therapeutic strategy after perinatal hypoxia is still limited. With the advent of promising therapy of hypothermia in HIE, this paper reviews the pathophysiology of HIE and the future potential neuroprotective strategies for clinical potential for hypoxia sufferers.
引用
收藏
页数：6
相关论文
共 58 条
[1]   Mild hypothermia after severe transient hypoxia-ischemia reduces the delayed rise in cerebral lactate in the newborn piglet [J].
Amess, PN ;
Penrice, J ;
Cady, EB ;
Lorek, A ;
Wylezinska, M ;
Cooper, CE ;
DSouza, P ;
Tyszczuk, L ;
Thoresen, M ;
Edwards, AD ;
Wyatt, JS ;
Reynolds, EOR .
PEDIATRIC RESEARCH, 1997, 41 (06) :803-808
[2]   GLUTAMATE-INDUCED NEURONAL DEATH - A SUCCESSION OF NECROSIS OR APOPTOSIS DEPENDING ON MITOCHONDRIAL-FUNCTION [J].
ANKARCRONA, M ;
DYPBUKT, JM ;
BONFOCO, E ;
ZHIVOTOVSKY, B ;
ORRENIUS, S ;
LIPTON, SA ;
NICOTERA, P .
NEURON, 1995, 15 (04) :961-973
[3]   Moderate Hypothermia to Treat Perinatal Asphyxial Encephalopathy. [J].
Azzopardi, Denis V. ;
Strohm, Brenda ;
Edwards, A. David ;
Dyet, Leigh ;
Halliday, Henry L. ;
Juszczak, Edmund ;
Kapellou, Olga ;
Levene, Malcolm ;
Marlow, Neil ;
Porter, Emma ;
Thoresen, Marianne ;
Whitelaw, Andrew ;
Brocklehurst, Peter .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (14) :1349-1358
[4]   Selective vulnerability of preterm white matter to oxidative damage defined by F2-isoprostanes [J].
Back, SA ;
Luo, NL ;
Mallinson, RA ;
O'Malley, JP ;
Wallen, LD ;
Frei, B ;
Morrow, JD ;
Petito, CK ;
Roberts, CT ;
Murdoch, GH ;
Montine, TJ .
ANNALS OF NEUROLOGY, 2005, 58 (01) :108-120
[5]  
Back SA, 1998, J NEUROSCI, V18, P6241
[6]   EXCITATORY AMINO-ACIDS CONTRIBUTE TO THE PATHOGENESIS OF PERINATAL HYPOXIC-ISCHEMIC BRAIN INJURY [J].
BARKS, JDE ;
SILVERSTEIN, FS .
BRAIN PATHOLOGY, 1992, 2 (03) :235-243
[7]   Protective effects of moderate hypothermia after neonatal hypoxia-ischemia:: Short- and long-term outcome [J].
Bona, E ;
Hagberg, H ;
Loberg, EM ;
Bågenholm, R ;
Thoresen, M .
PEDIATRIC RESEARCH, 1998, 43 (06) :738-745
[8]   PROTECTION AGAINST HIPPOCAMPAL CA1 CELL LOSS BY POSTISCHEMIC HYPOTHERMIA IS DEPENDENT ON DELAY OF INITIATION AND DURATION [J].
CARROLL, M ;
BEEK, O .
METABOLIC BRAIN DISEASE, 1992, 7 (01) :45-50
[9]  
CHOI DW, 1990, ANNU REV NEUROSCI, V13, P171, DOI 10.1146/annurev.neuro.13.1.171
[10]   Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data [J].
Edwards, A. David ;
Brocklehurst, Peter ;
Gunn, Alistair J. ;
Halliday, Henry ;
Juszczak, Edmund ;
Levene, Malcolm ;
Strohm, Brenda ;
Thoresen, Marianne ;
Whitelaw, Andrew ;
Azzopardi, Denis .
BMJ-BRITISH MEDICAL JOURNAL, 2010, 340 :409
123456