Immunoendocrine Dysregulation during Gestational Diabetes Mellitus: The Central Role of the Placenta

被引：55

作者：

Olmos-Ortiz, Andrea ^{[1
]}

Flores-Espinosa, Pilar ^{[1
]}

Diaz, Lorenza ^{[2
]}

Velazquez, Pilar ^{[3
]}

Ramirez-Isarraraz, Carlos ^{[4
]}

Zaga-Clavellina, Veronica ^{[5
]}

机构：

[1] Inst Nacl Perinatol Isidro Espinosa Reyes INPer, Dept Inmunobioquim, Ciudad De Mexico 11000, Mexico

[2] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Biol Reprod, Ciudad De Mexico 14080, Mexico

[3] Hosp Angeles Mexico, Dept Ginecol & Obstet, Ciudad De Mexico 11800, Mexico

[4] Inst Nacl Perinatol Isidro Espinosa Reyes INPer, Clin Urol Ginecol, Ciudad De Mexico 11000, Mexico

[5] Inst Nacl Perinatol Isidro Espinosa Reyes INPer, Dept Fisiol & Desarrollo Celular, Ciudad De Mexico 11000, Mexico

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 15期

关键词：

inflammation; cytokines; adipokines; antimicrobial peptides; oxidative stress; metabolic stress; IGF-I; insulin; lactotroph hormones; angiogenesis; ENDOTHELIAL GROWTH-FACTOR; I HYBRID RECEPTORS; HUMAN CHORIONIC-GONADOTROPIN; VITAMIN-D DEFICIENCY; FACTOR-KAPPA-B; OXIDATIVE STRESS; INSULIN-RESISTANCE; ADIPOSE-TISSUE; HIGH GLUCOSE; PROINFLAMMATORY CYTOKINES;

D O I：

10.3390/ijms22158087

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gestational Diabetes Mellitus (GDM) is a transitory metabolic condition caused by dysregulation triggered by intolerance to carbohydrates, dysfunction of beta-pancreatic and endothelial cells, and insulin resistance during pregnancy. However, this disease includes not only changes related to metabolic distress but also placental immunoendocrine adaptations, resulting in harmful effects to the mother and fetus. In this review, we focus on the placenta as an immuno-endocrine organ that can recognize and respond to the hyperglycemic environment. It synthesizes diverse chemicals that play a role in inflammation, innate defense, endocrine response, oxidative stress, and angiogenesis, all associated with different perinatal outcomes.

引用

页数：33

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