Big Bang and context-driven collapse

被引：16

作者：

Robertson-Tessi, Mark ^{[1
]}

Anderson, Alexander R. A. ^{[1
]}

机构：

[1] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Integrated Math Oncol Dept, Tampa, FL 33612 USA

来源：

NATURE GENETICS | 2015年 / 47卷 / 03期

关键词：

CANCER; HETEROGENEITY; EVOLUTION; POPULATIONS; THERAPY; TUMORS;

D O I：

10.1038/ng.3231

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Heterogeneity is the single most important factor driving cancer progression and treatment failure, yet little is understood about how and when this heterogeneity arises. A new study shows that colorectal cancers acquire their dominant mutations early in development and that subsequent mutations, even if they confer greater fitness, are unlikely to sweep through the tumor.

引用

页码：196 / 197

页数：3

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