Synthesis and evaluation of antifungal properties of a series of the novel 2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile and its analogues

被引：129

作者：

Gholap, Atul R.

Toti, Kiran S.

Shirazi, Fazal

Kumari, Ratna

Bhat, Manoj Kumar

Deshpande, Mukund V.

Srinivasan, Kumar V. ^{[1
]}

机构：

[1] Natl Chem Lab, Div Organ Chem Technol, Pune 411008, Maharashtra, India

[2] Natl Chem Lab, Div Biochem Sci, Pune 411008, Maharashtra, India

[3] Univ Poona, Natl Ctr Cell Sci, Pune 411007, Maharashtra, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2007年 / 15卷 / 21期

关键词：

arylidenemalononitriles; Michael addition; arylquinoline carbonitrile; antifungal activity; antiproliferative activity;

D O I：

10.1016/j.bmc.2007.08.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of 2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile and various analogues have been synthesized in excellent isolated yields starting from various arylidenemalononitrile and 3-amino-2-cyclohexen-1-one in 1-propanol as solvent at reflux temperature in the absence of any added catalyst. All the synthesized compounds were evaluated for their antifungal activity. The relationship between functional group variation and biological activity of the evaluated compounds is discussed in the article. (C) 2007 Elsevier Ltd. All rights reserved.

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收藏

页码：6705 / 6715

页数：11

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