Co-evolution of X-chromosome inactivation and imprinting in mammals

被引：196

作者：

Reik, W ^{[1
]}

Lewis, A ^{[1
]}

机构：

[1] Babraham Inst, Lab Dev Genet & Imprinting, Cambridge CB2 4AT, England

来源：

NATURE REVIEWS GENETICS | 2005年 / 6卷 / 05期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

D O I：

10.1038/nrg1602

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recent studies have revealed mechanistic parallels between imprinted X-chromosome inactivation and autosomal imprinting. We suggest that neither mechanism was present in ancestral egg-laying mammals, and that both arose when the evolution of the placenta exerted selective pressure to imprint growth-related genes. We also propose that non-coding RNAs and histone modifications were adopted for the imprinting of growth suppressors on the X chromosome and on autosomes. This provides a unified hypothesis for the evolution of X-chromosome inactivation and imprinting.

引用

页码：403 / 410

页数：9

共 71 条

[1] Dosage compensation: an intertwined world of RNA and chromatin remodelling [J].