Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study

被引：6

作者：

Kaitu'u-Lino, Tu'uhevaha J. ^{[1
,2
,3
]}

Tong, Stephen ^{[1
,2
,3
]}

Walker, Susan P. ^{[2
,3
]}

MacDonald, Teresa M. ^{[2
,3
]}

Cannon, Ping ^{[1
,2
]}

Nguyen, Tuong-Vi ^{[1
,2
]}

Sadananthan, Suresh Anand ^{[4
]}

Tint, Mya-Thway ^{[4
,5
,6
]}

Ong, Yi Ying ^{[7
]}

Ling, Loy See ^{[4
,8
,9
]}

Gluckman, Peter D. ^{[4
,13
]}

Chong, Yap-Seng ^{[4
,5
,6
]}

Godfrey, Keith M. ^{[10
]}

Chan, Shiao-Yng ^{[4
,5
,6
]}

Tan, Kok Hian ^{[14
]}

Lee, Yung Seng ^{[4
,7
]}

Michael, Navin ^{[4
,13
]}

Eriksson, Johan G. ^{[4
,5
,6
,11
,12
,13
]}

Wlodek, Mary E. ^{[2
,4
,5
,6
,13
]}

机构：

[1] Mercy Hosp Women, Translat Obstet Grp, 163 Studley Rd, Heidelberg, Vic 3084, Australia

[2] Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Melbourne, Vic, Australia

[3] Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia

[4] Singapore Inst Clin Sci, Agcy Sci, Technol & Res ASTAR, Singapore, Singapore

[5] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Obstet & Gynaecol, Singapore, Singapore

[6] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Human Potential Translat Res Programme, Singapore, Singapore

[7] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Paediat, Singapore, Singapore

[8] KK Womens & Childrens Hosp, Dept Reprod Med, Singapore 229899, Singapore

[9] DukeNUS Med Sch, Singapore 169857, Singapore

[10] Univ Southampton, Univ Hosp Southampton NHS Fdn Trust, NIHR Southampton Biomed Res Ctr, MRC Lifecourse Epidemiol Unit, Southampton, Hants, England

[11] Univ Helsinki, Helsinki Univ Hosp, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland

[12] Folkalsan Res Ctr, Helsinki, Finland

[13] Univ Auckland, Liggins Inst, Auckland, New Zealand

[14] KK Womens & Childrens Hosp Singapore, Dept Maternal FetaL Med, Singapore, Singapore

来源：

PLACENTA | 2021年 / 110卷

基金：

英国医学研究理事会;

关键词：

SGA; Biomarker; SPINT1; Fetal growth restriction; BIRTH-WEIGHT;

D O I：

10.1016/j.placenta.2021.05.007

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fetal growth restriction arising from placental insufficiency is a leading cause of stillbirth. We recently identified low maternal circulating SPINT1 concentrations as a novel biomarker of poor fetal growth. Here we measured SPINT1 in a prospective cohort in Singapore. Circulating SPINT1 concentrations were significantly lower among 141 pregnant women destined to deliver small-for-gestational age infants (birthweight <10th centile), compared to 772 controls (p < 0.01) at as early as 26 weeks' gestation. There were no correlations between infant body composition and circulating SPINT1 concentrations at 26 weeks. This provides validation that low maternal SPINT1 concentration is associated with poor fetal growth.

引用

页码：24 / 28

页数：5

共 12 条

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