Induced pluripotent stem cell-derived neural stem cell therapies for spinal cord injury

被引：25

作者：

Lee-Kubli, Corinne A. ^{[1
]}

Lu, Paul ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA

[2] Vet Adm Med Ctr, San Diego, CA 92161 USA

来源：

NEURAL REGENERATION RESEARCH | 2015年 / 10卷 / 01期

关键词：

transplantation; axonal growth; axonal regeneration; neuroprotection; remyelination; differentiation; neuronal relay; human; astrocytes; neurons; oligodendrocytes; secondary degeneration; ADULT HUMAN FIBROBLASTS; DIRECT CONVERSION; MOUSE FIBROBLASTS; PROGENITOR CELLS; AXONAL GROWTH; NEURONS; GENERATION; INDUCTION; TRANSPLANTATION; REGENERATION;

D O I：

10.4103/1673-5374.150638

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The greatest challenge to successful treatment of spinal cord injury is the limited regenerative capacity of the central nervous system and its inability to replace lost neurons and severed axons following injury. Neural stem cell grafts derived from fetal central nervous system tissue or embryonic stem cells have shown therapeutic promise by differentiation into neurons and glia that have the potential to form functional neuronal relays across injured spinal cord segments. However, implementation of fetal-derived or embryonic stem cell-derived neural stem cell therapies for patients with spinal cord injury raises ethical concerns. Induced pluripotent stem cells can be generated from adult somatic cells and differentiated into neural stem cells suitable for therapeutic use, thereby providing an ethical source of implantable cells that can be made in an autologous fashion to avoid problems of immune rejection. This review discusses the therapeutic potential of human induced pluripotent stem cell-derived neural stem cell transplantation for treatment of spinal cord injury, as well as addressing potential mechanisms, future perspectives and challenges.

引用

页码：10 / 16

页数：7

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