Pleiotropic Effects of Modified Citrus Pectin

被引：88
作者：
Eliaz, Isaac [1 ]
Raz, Avraham [2 ,3 ,4 ]
机构：
[1] Amitabha Med Clin & Healing Ctr, 398 Tesconi Ct, Santa Rosa, CA 95401 USA
[2] Wayne State Univ, Sch Med, Dept Oncol, 4100 John R St, Detroit, MI 48201 USA
[3] Wayne State Univ, Sch Med, Dept Pathol, 4100 John R St, Detroit, MI 48201 USA
[4] Barbara Ann Karmanos Canc Inst, 4100 John R St, Detroit, MI 48201 USA
来源：
NUTRIENTS | 2019年 / 11卷 / 11期
关键词：
cancer; cardiovascular; fibrosis; galectin; inflammation; pectasol; PROSTATE-CANCER CELLS; HUMAN BREAST; GALECTIN-3; INHIBITION; PHARMACOLOGICAL INHIBITION; INDUCED APOPTOSIS; CYCLE ARREST; GROWTH; EXPRESSION; ADHESION; CARCINOMA;
D O I：
10.3390/nu11112619
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Modified citrus pectin (MCP) has a low-molecular-weight degree of esterification to allow absorption from the small intestinal epithelium into the circulation. MCP produces pleiotropic effects, including but not limited to its antagonism of galectin-3, which have shown benefit in preclinical and clinical models. Regarding cancer, MCP modulates several rate-limiting steps of the metastatic cascade. MCP can also affect cancer cell resistance to chemotherapy. Regarding fibrotic diseases, MCP modulates many of the steps involved in the pathogenesis of aortic stenosis. MCP also reduces fibrosis to the kidney, liver, and adipose tissue. Other benefits of MCP include detoxification and improved immune function. This review summarizes the pleiotropic effects of MCP.
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页数：18
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