Synthesis of highly fluorescent hydrophobic carbon dots by hot injection method using Paraplast as precursor

被引：52

作者：

Talib, Abou ^{[3
]}

Pandey, Sunil ^{[1
,2
]}

Thakur, Mukeshchand ^{[1
]}

Wu, Hui-Fen ^{[1
,2
,3
,4
,5
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 80424, Taiwan

[2] Natl Sun Yat Sen Univ, Ctr Nanosci & Nanotechnol, Kaohsiung 80424, Taiwan

[3] Natl Sun Yat Sen Univ, Doctoral Degree Program Marine Biotechnol, Kaohsiung 80424, Taiwan

[4] Kaohsiung Med Univ, Sch Pharm, Coll Pharm, Kaohsiung 800, Taiwan

[5] Natl Sun Yat Sen Univ, Inst Med Sci & Technol, Kaohsiung 80424, Taiwan

来源：

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2015年 / 48卷

关键词：

Hydrophobic; Carbon dots; Paraplast; Breast cancer stem cells; Biological imaging; ONE-STEP SYNTHESIS; NANOTECHNOLOGY; CYTOTOXICITY; NANODOTS; DELIVERY;

D O I：

10.1016/j.msec.2014.11.058

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

We have reported synthesis of bright blue colored hydrophobic carbon dots (hC-dots) using highly pure blend of polymers called Paraplast We developed a hot injection method for making nearly monodispersed hC-dots with a diameter in a range: 5-30 nm as confirmed by high resolution transmission electron microscopy (HRTEM). The involvement of various functional groups was confirmed by Fourier transform infra-red (FTIR) spectroscopy. These hC-dots were incubated with breast cancer stem cells in order to check the entry as well as biological imaging. The cells were analyzed using epifluorescent microscopy. hC-dots showed concentration dependent cytotoxicity (LD50: 50 mg/ml) and could be used for bioimaging even at lower concentration (0.5 mg/ml). hC-dots were found to be versatile agents for peeping inside the cells which could also be used for delivery of water insoluble chemotherapeutic agents to variety of solid tumors. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：700 / 703

页数：4

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