Evaluation of apramycin activity against carbapenem-resistant and -susceptible strains of Enterobacteriaceae

被引：38

作者：

Smith, Kenneth P. ^{[1
]}

Kirby, James E. ^{[1
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Dept Pathol, 330 Brookline Ave YA309, Boston, MA 02215 USA

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2016年 / 86卷 / 04期

关键词：

Apramycin; Aminoglycoside; Carbapenem-resistant Enterobacteriaceae; Repurposing; Multidrug-resistance; Activity spectrum; AMINOGLYCOSIDE RESISTANCE; PHARMACOKINETICS; ANTIBIOTICS; MECHANISM; OPTIONS;

D O I：

10.1016/j.diagmicrobio.2016.09.002

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We evaluated activity of apramycin, a non-ototoxic/non-nephrotoxic aminocyclitol against 141 clinical Enterobacteriaceae isolates, 51% of which were non-susceptible to carbapenems (CRE). Among CRE, 70.8% were apramycin susceptible, which compared favorably to aminoglycosides in current clinical use. Our data suggest that apramycin deserves further investigation as a repurposed, anti-CRE therapeutic. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：439 / 441

页数：3

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