Multiple Defects, Including Premature Apoptosis, Prevent Kaposi's Sarcoma-Associated Herpesvirus Replication in Murine Cells
被引:20
作者:
Austgen, Kathryn
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Microbiol, GW Hooper Fdn, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Med, GW Hooper Fdn, San Francisco, CA USAUniv Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
Austgen, Kathryn
[1
,2
,3
]
Oakes, Scott A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94140 USAUniv Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
Oakes, Scott A.
[4
]
Ganem, Don
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Microbiol, GW Hooper Fdn, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Med, GW Hooper Fdn, San Francisco, CA USAUniv Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
Ganem, Don
[1
,2
,3
]
机构:
[1] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Microbiol, GW Hooper Fdn, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Dept Med, GW Hooper Fdn, San Francisco, CA USA
[4] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94140 USA
The development of a mouse model for Kaposi's sarcoma-associated herpesvirus (KSHV) infection has been impeded by the limited host range of the virus. Here, we have examined the molecular basis of this host range restriction. KSHV efficiently enters murine cells and establishes latency. However, ectopic expression of the lytic switch protein RTA (replication and transcription activator) in these cells induces little viral gene expression and no virus production. Upon treatment with histone deacetylase inhibitors, KSHV-infected murine cells display more extensive but aberrant viral transcription and do not support either viral DNA synthesis or the production of infectious virions. These aberrantly infected cells also display markedly enhanced apoptosis. Genetic ablation of the mitochondrial apoptotic pathway in these cells prolongs their survival and permits viral DNA replication but does not rescue the generation of virions. We conclude that multiple defects, both prior to and following DNA synthesis, restrict lytic KSHV infection in murine cells.
机构:Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
Chandriani, Sanjay
Ganem, Don
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USAUniv Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
机构:
Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Southborough, MA 01772 USA
Harvard Univ, Sch Med, Div Tumor Virol, New England Primate Res Ctr, Southborough, MA 01772 USAUniv So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Chang, Heesoon
Wachtman, Lynn M.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Primate Med Div, New England Primate Res Ctr, Southborough, MA 01772 USAUniv So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Wachtman, Lynn M.
Pearson, Christine B.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Primate Med Div, New England Primate Res Ctr, Southborough, MA 01772 USAUniv So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Pearson, Christine B.
论文数: 引用数:
h-index:
机构:
Lee, Jong-Soo
Lee, Hye-Ra
论文数: 0引用数: 0
h-index: 0
机构:
Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Southborough, MA 01772 USA
Harvard Univ, Sch Med, Div Tumor Virol, New England Primate Res Ctr, Southborough, MA 01772 USAUniv So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Lee, Hye-Ra
Lee, Steven H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Southborough, MA 01772 USA
Harvard Univ, Sch Med, Div Tumor Virol, New England Primate Res Ctr, Southborough, MA 01772 USAUniv So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Lee, Steven H.
Vieira, Jeffrey
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Lab Med, Seattle, WA 98195 USAUniv So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Vieira, Jeffrey
Mansfield, Keith G.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Primate Med Div, New England Primate Res Ctr, Southborough, MA 01772 USAUniv So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Mansfield, Keith G.
Jung, Jae U.
论文数: 0引用数: 0
h-index: 0
机构:
Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Southborough, MA 01772 USA
Harvard Univ, Sch Med, Div Tumor Virol, New England Primate Res Ctr, Southborough, MA 01772 USAUniv So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
机构:Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
Chandriani, Sanjay
Ganem, Don
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USAUniv Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
机构:
Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Southborough, MA 01772 USA
Harvard Univ, Sch Med, Div Tumor Virol, New England Primate Res Ctr, Southborough, MA 01772 USAUniv So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Chang, Heesoon
Wachtman, Lynn M.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Primate Med Div, New England Primate Res Ctr, Southborough, MA 01772 USAUniv So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Wachtman, Lynn M.
Pearson, Christine B.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Primate Med Div, New England Primate Res Ctr, Southborough, MA 01772 USAUniv So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Pearson, Christine B.
论文数: 引用数:
h-index:
机构:
Lee, Jong-Soo
Lee, Hye-Ra
论文数: 0引用数: 0
h-index: 0
机构:
Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Southborough, MA 01772 USA
Harvard Univ, Sch Med, Div Tumor Virol, New England Primate Res Ctr, Southborough, MA 01772 USAUniv So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Lee, Hye-Ra
Lee, Steven H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Southborough, MA 01772 USA
Harvard Univ, Sch Med, Div Tumor Virol, New England Primate Res Ctr, Southborough, MA 01772 USAUniv So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Lee, Steven H.
Vieira, Jeffrey
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Lab Med, Seattle, WA 98195 USAUniv So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Vieira, Jeffrey
Mansfield, Keith G.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Primate Med Div, New England Primate Res Ctr, Southborough, MA 01772 USAUniv So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Mansfield, Keith G.
Jung, Jae U.
论文数: 0引用数: 0
h-index: 0
机构:
Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Southborough, MA 01772 USA
Harvard Univ, Sch Med, Div Tumor Virol, New England Primate Res Ctr, Southborough, MA 01772 USAUniv So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA