AFM Studies on Curcumin Based Zn(II) Complex Molecules for Applications as Anticancer Agents

被引：1
|
作者：
Tone, C. M. [1 ]
Pirillo, S. [2 ]
Pucci, D. [2 ]
De Santo, M. P. [1 ]
Barberi, R. C. [1 ]
Ciuchi, F. [1 ]
机构：
[1] Univ Calabria, Dept Phys, IPCF CNR UOS Cosenza, I-87036 Arcavacata Di Rende, CS, Italy
[2] Univ Calabria, Dept Chem, I-87036 Arcavacata Di Rende, CS, Italy
来源：
MOLECULAR CRYSTALS AND LIQUID CRYSTALS | 2012年 / 558卷
关键词：
Afm; anticancer molecules; chromonic liquid crystals; ATOMIC-FORCE MICROSCOPY; DNA; BINDING; INTERCALATION;
D O I：
10.1080/15421406.2011.654188
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We present our recent atomic force microscopy studies on a curcumin based Zn(II) complex anticancer agent. We investigated the morphology of the molecule on a nanoscale level to test the effect of different substrates and solvents on the shape and the aggregation properties of the molecule. Self assembled films were produced by Langmuir technique at different surface pressures and by spin coating. Measurements showed small molecular aggregates with a height of 0,5 nm. The wetting properties of the substrate play a role in the aggregation properties and the film formation. The obtained results will help in understanding the interaction of the studied molecule with DNA or chromonic systems.
引用
收藏
页码：194 / 203
页数：10
相关论文
共 50 条
  • [21] Spectral and toxicological studies of complex Zn(II) with tetracycline
    Guru, P
    Goutam, MP
    Gautam, RK
    MAIN GROUP METAL CHEMISTRY, 2003, 26 (02): : 141 - 153
  • [22] Interaction of curcumin with Zn(II) and Cu(II) ions based on experiment and theoretical calculation
    Zhao, Xue-Zhou
    Jiang, Teng
    Wang, Long
    Yang, Hao
    Zhang, Sui
    Zhou, Ping
    JOURNAL OF MOLECULAR STRUCTURE, 2010, 984 (1-3) : 316 - 325
  • [23] Design of new Zn(II) pyrazine and pyridine derivatives based complexes as potential anticancer agents: from synthesis to structure
    Climova, Alina
    Pivovarova, Ekaterina
    Szczesio, Malgorzata
    Olczak, Andrzej
    Wojciechowski, Jakub
    Gobis, Katarzyna
    Ziembicka, Dagmara
    Korga-Plewko, Agnieszka
    Kubik, Joanna
    Iwan, Magdalena
    Korona-Glowniak, Izabela
    Czylkowska, Agnieszka
    POLYHEDRON, 2023, 245
  • [24] Zn(II) and Cd(II) complexes of dithiocarbamate ligands: synthesis, characterization, anticancer, and theoretical studies
    Abdalrazaq, Eid A.
    Abu-Yamin, Abdel-Aziz
    Taher, Deeb
    Hassan, Abdullah E.
    Elhenawy, Ahmed A.
    JOURNAL OF SULFUR CHEMISTRY, 2024, 45 (05) : 714 - 739
  • [25] Vibrational Spectroscopy Studies on Biologically Relevant Molecules: From Anticancer Agents to Drugs of Abuse
    Marques, M. P. M.
    Borges, F.
    Amorim da Costa, A. M.
    Batista de Carvalho, L. A. E.
    NEW APPROACHES IN BIOMEDICAL SPECTROSCOPY, 2007, 963 : 338 - +
  • [26] Synthesis, crystal structure and in vitro anticancer studies of bis(dibenzyldithiocarbamato)Zn(II)
    Ajibade, Peter A.
    Sikakane, Berlinda M.
    Oluwalana, Abimbola E.
    Paca, Athandwe M.
    Singh, Moganavelli
    JOURNAL OF COORDINATION CHEMISTRY, 2021, 74 (08) : 1244 - 1254
  • [27] Imidazolylpyrrolone-Based Small Molecules as Anticancer Agents for Renal Cell Carcinoma
    Sousa, Ana
    Pontes, Olivia
    Andrade, Juliana
    Baltazar, Fatima
    Costa, Marta
    Proenca, Fernanda
    CHEMMEDCHEM, 2023, 18 (02)
  • [28] Synthesis, spectral and toxicological studies of complex Zn(II) with sulfadiazine
    Guru, P
    Gautam, RK
    Goutam, BP
    CHEMICAL PAPERS-CHEMICKE ZVESTI, 2004, 58 (05): : 341 - 347
  • [29] DNA binding and cytotoxicity of fluorescent curcumin-based Zn(II) complexes
    Pucci, Daniela
    Bellini, Tommaso
    Crispini, Alessandra
    D'Agnano, Igea
    Liguori, Paola F.
    Garcia-Orduna, Pilar
    Pirillo, Sante
    Valentini, Alessandra
    Zanchetta, Giuliano
    MEDCHEMCOMM, 2012, 3 (04) : 462 - 468
  • [30] Triazole-based Mn(II), Fe(II), Ni(II), Cu(II) and Zn(II) complexes as potential anticancer agents - Physicochemical properties, in silico predictions and in vitro activity
    Czylkowska, Agnieszka
    Pitucha, Monika
    Lanka, Suneel
    Raducka, Anita
    Rogalewicz, Bartlomiej
    Szczesio, Malgorzata
    Swiatkowski, Marcin
    Zarczynski, Andrzej
    Klepacz-Smotka, Anna
    Szczytko, Jacek
    Camargo, Bruno
    Drabinska, Aneta
    Szymanski, Pawel
    POLYHEDRON, 2024, 261
12345