An introduction to quadrupole-time-of-flight mass spectrometry

被引：453
|
作者：
Chernushevich, IV [1 ]
Loboda, AV [1 ]
Thomson, BA [1 ]
机构：
[1] MDS SCIEX, Concord, ON L4K 4V8, Canada
来源：
JOURNAL OF MASS SPECTROMETRY | 2001年 / 36卷 / 08期
关键词：
time-of-flight mass spectrometry; quadrupole mass spectrometry; collision-induced dissociation; electrospray; matrix-assisted laser desorption/ionization;
D O I：
10.1002/jms.207
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A brief introduction is presented to the basic principles and application of a quadrupole-time-of-flight (TOF) tandem mass spectrometer. The main features of reflecting TOF instruments with orthogonal injection of ions are discussed. Their operation and performance are compared with those of triple quadrupoles with electrospray ionization and matrix-assisted laser desorption/ionization (MALDI) TOF mass spectrometers. Examples and recommendations are provided for all major operational modes: mass spectrometry (MS) and tandem MS (MS/MS), precursor ion scans and studies of non-covalent complexes: Basic algorithms for liquid chromatography/MS/MS automation are discussed and illustrated by two applications. Copyright (C) 2001 John Wiley & Sons, Ltd.
引用
收藏
页码：849 / 865
页数：21
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