The Role of Lymphovascular Invasion as a Prognostic Factor in Patients with Lymph Node-Positive Operable Invasive Breast Cancer

被引:80
|
作者
Song, Young Ju [1 ]
Shin, Sun Hyoung [1 ]
Cho, Jin Seong [1 ]
Park, Min Ho [1 ]
Yoon, Jung Han [1 ]
Jegal, Young Jong [1 ]
机构
[1] Chonnam Natl Univ, Sch Med, Dept Surg, Kwangju 501757, South Korea
关键词
Breast neoplasms; Lymph node metastasis; Lymphovascular invasion; Prognostic factor; VASCULAR INVASION; CARCINOMA; SURVIVAL; EMBOLI;
D O I
10.4048/jbc.2011.14.3.198
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: Lymphovascular invasion (LVI) is an important prognostic factor in patients with lymph node-negative patients with invasive breast cancer. However, the prognostic value of LVI it is unclear and controversial about its prognostic value in patients with lymph node-positive breast cancer patients. So, we report the an analysis of the prognostic significance of LVI in a large cohort study of patients with lymph node-positive patients with invasive breast cancer. Methods: We retrospectively reviewed 967 patients with invasive breast cancer that had undergone surgical treatment at our hospital, from January 2004 to December 2007. Among these thempatients, 349 patients with lymph node-positive breast cancer patients are were included in this study. We evaluated clinical and pathological data in these patients, we compared with 5-year overall survival and disease-free survival between an LVI-present group and an LVI-absent group. Results: The median follow-up was 48 months (range, 12-78 months), and the mean age of the patients was 48 years (range, 23-78 years). LVI was present in 192 patients (55%) of with tumors and was associated with age <= 40 years (p=0.009), high histologichistological grade (p=0.007), estrogen receptor status (p=0.001),tumor size >= 2 cm (p<0.001), and number of involved lymph nodes (p<0.001), but not with progesterone receptor status, HER2 status, p53 status, or tumor multiplicity. LVI was a significant independent prognostic factor for disease-free survival (p<0.001) and overall survival (p=0.006). By multivariate analysis revealed that LVI (p=0.003), number of involved lymph nodes (>= 4; p=0.005), and high histological grade (II and III; p=0.02) was were an independent significant predictors of disease-free survival and overall survival in the whole group of patients. Conclusion: In this case, we demonstrated that LVI is a significant predictor of poor prognosis in patients with lymph node-positive patients with primary invasive breast cancer, LVI is a significant predictive predictor value of poor prognosis. So, LVI should be considered in the therapeutic strategy as a decision making tool in the adjuvant chemotherapy setting.
引用
收藏
页码:198 / 203
页数:6
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