Active Pharmaceutical Ingredients Transportation and Release from Aerogel Particles Processes Modeling

被引：5

作者：

Lebedev, Igor ^{[1
]}

Uvarova, Anastasia ^{[1
]}

Mochalova, Maria ^{[1
]}

Menshutina, Natalia ^{[1
]}

机构：

[1] Mendeleev Univ Chem Technol Russia, Dept Chem & Pharmaceut Engn, Moscow 125047, Russia

来源：

COMPUTATION | 2022年 / 10卷 / 08期

关键词：

aerogels; chitosan; melatonin; cellular automata; modeling; lattice Boltzmann method; API; DELIVERY;

D O I：

10.3390/computation10080139

中图分类号：

O1 [数学];

学科分类号：

0701 ; 070101 ;

摘要：

In this work, active pharmaceutical ingredients release from aerogel particles and active pharmaceutical ingredients transportation processes were investigated. Experimental studies were carried out on the release of various types of active pharmaceutical ingredients from various types of aerogel particles. Release curves were obtained. A hybrid model using the lattice Boltzmann method and a cellular automata approach to simulate the release of active pharmaceutical ingredients from aerogel particles and active pharmaceutical ingredients transport processes is proposed. The proposed model can be used in new drug development, which allows partially replacing full-scale experiments with computational ones, therefore reducing the experimental studies cost.

引用

页数：20

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