Diterpenes from Grangea maderaspatana

被引：10

作者：

Chang, Fang-Rong ^{[1
,2
,3
]}

Huang, Shih-Ting ^{[1
]}

Liaw, Chih-Chuang ^{[4
]}

Yen, Ming-Hong ^{[1
,5
]}

Hwang, Tsong-Long ^{[6
,7
,8
,9
,10
]}

Chen, Ching-Yeu ^{[11
]}

Hou, Ming-Feng ^{[2
,3
]}

Yuan, Shyng-Shiou ^{[2
,3
]}

Cheng, Yuan-Bin ^{[1
,12
]}

Wu, Yang-Chang ^{[1
,13
,14
,15
,16
]}

机构：

[1] Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[2] Kaohsiung Med Univ Hosp, Translat Res Ctr, Kaohsiung 807, Taiwan

[3] Kaohsiung Med Univ Hosp, Ctr Canc, Kaohsiung 807, Taiwan

[4] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[5] Kaohsiung Med Univ, Coll Pharm, Sch Pharm, Kaohsiung 807, Taiwan

[6] Chang Gung Univ, Coll Med, Sch Tradit Chinese Med, Grad Inst Nat Prod, Taoyuan 333, Taiwan

[7] Chang Gung Univ, Hlth Aging Res Ctr, Chinese Herbal Med Res Team, Taoyuan 333, Taiwan

[8] Chang Gung Univ Sci & Technol, Res Ctr Ind Human Ecol, Taoyuan 333, Taiwan

[9] Chang Gung Univ Sci & Technol, Grad Inst Hlth Ind Technol, Taoyuan 333, Taiwan

[10] Chang Gung Mem Hosp, Immunol Consortium, Taoyuan 333, Taiwan

[11] Tzu Hui Inst Technol, Dept Phys Therapy, Pingtung 926, Taiwan

[12] Kaohsiung Med Univ, Res Ctr Nat Prod & Drug Dev, Kaohsiung 807, Taiwan

[13] China Med Univ, Coll Pharm, Sch Pharm, Taichung 404, Taiwan

[14] China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 404, Taiwan

[15] China Med Univ Hosp, Ctr Mol Med, Taichung 404, Taiwan

[16] China Med Univ, Res Ctr Chinese Herbal Med, Taichung 404, Taiwan

来源：

PHYTOCHEMISTRY | 2016年 / 131卷

关键词：

Grangea maderaspatana; Asteraceae; Diterpenes; Anti-inflammatory; INHIBITS SUPEROXIDE-PRODUCTION; CLERODANE DERIVATIVES; POLYALTHIA-LONGIFOLIA; HUMAN NEUTROPHILS; FLAVONOIDS; STEREOCHEMISTRY; CONSTITUENTS; POIR; RATS;

D O I：

10.1016/j.phytochem.2016.08.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phytochemical investigation of the ethanolic extract of Grangea maderaspatana led to isolation of gramaderins A-D, together with thirteen known compounds. All isolates were assayed for their anti-inflammatory activities. Consequently, 5,7-dihydroxy-3,6,3',4',5'-pentamethoxyflavone and 5,3'-dihydroxy-3,6,7,4',5'-pentamethoxyflavone showed significant bioactivities by inhibiting superoxide anion generation. 8-Acetoxy-pentadeca-1,9Z,14-trien-4.6-diyne-3-ol also demonstrated potent inhibition on elastase release. The gramaderins A/C (beta-alkyl linked gamma-lactone) and gramaderins B/D (alpha-alkyl linked gamma-lactone) co-exist in this plant material, of which the latter derivatives are few in nature. Gramaderins C/D possess a special linear dilactone diterpene skeleton, which never been reported. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：124 / 129

页数：6

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