Spatial coordination of spindle assembly by chromosome-mediated signaling gradients

被引：227
作者：
Caudron, M
Bunt, G
Bastiaens, P [1 ]
Karsenti, E
机构：
[1] European Mol Biol Lab, Cell Biol & Biophys Dept, D-69117 Heidelberg, Germany
[2] Max Planck Inst Expt Med, D-37075 Gottingen, Germany
来源：
SCIENCE | 2005年 / 309卷 / 5739期
关键词：
D O I：
10.1126/science.1115964
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
During cell division, chromosomes are distributed to daughter cells by the mitotic spindle. This system requires spatial cues to reproducibly self-organize. We report that such cues are provided by chromosome-mediated interaction gradients between the small guanosine triphosphatase (GTPase) Ran and importin-beta. This produces activity gradients that determine the spatial distribution of microtubule nucleation and stabilization around chromosomes and that are essential for the self-organization of microtubules into a bipolar spindle.
引用
收藏
页码：1373 / 1376
页数：4
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