Measuring Permeability in Acute Ischemic Stroke

被引：33

作者：

Kassner, Andrea ^{[1
]}

Mandell, Daniel M. ^{[2
]}

Mikulis, David J. ^{[2
]}

机构：

[1] Univ Toronto, Dept Med Imaging, Toronto, ON M5S 3E2, Canada

[2] Univ Toronto, Toronto Western Hosp, Dept Med Imaging, Toronto, ON M5T 2S8, Canada

来源：

NEUROIMAGING CLINICS OF NORTH AMERICA | 2011年 / 21卷 / 02期

基金：

加拿大健康研究院;

关键词：

MRI; CT; Stroke; Dynamic contrast-enhanced imaging; Hemorrhagic transformation; Permeability; BLOOD-BRAIN-BARRIER; TISSUE-PLASMINOGEN ACTIVATOR; PERFUSION CT ASSESSMENT; TIME UPTAKE DATA; HEMORRHAGIC TRANSFORMATION; TRANSFER CONSTANTS; MICROVASCULAR PERMEABILITY; CONTRAST ENHANCEMENT; GRAPHICAL EVALUATION; RECIRCULATION PHASE;

D O I：

10.1016/j.nic.2011.01.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The blood-brain barrier (BBB) is a functional concept to describe unique features of intracranial blood vessels that prevent many substances in the systemic circulation from entering the brain. In the setting of acute ischemic stroke, loss of blood-brain barrier (BBB) integrity is believed to be a precursor to hemorrhagic transformation. CT and MR imaging may evaluate BBB integrity by detecting leakage of intravenously administered contrast media into the extravascular space. In its simplest form, BBB integrity is assessed qualitatively, by determining the presence or absence of contrast enhancement on structural images of the brain. When dynamic contrast-enhanced (DCE) MRI or CT is combined with a suitable pharmacokinetic model, one can quantify and spatially map BBB integrity throughout the brain.

引用

页码：315 / +

页数：13

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