A census of the lung: CellCards from LungMAP

被引：85

作者：

Sun, Xin ^{[1
,2
]}

Perl, Anne-Karina ^{[3
,4
]}

Li, Rongbo ^{[1
]}

Bell, Sheila M. ^{[3
]}

Sajti, Eniko ^{[1
]}

Kalinichenko, Vladimir V. ^{[3
,4
,5
]}

Kalin, Tanya, V ^{[3
,4
]}

Misra, Ravi S. ^{[6
]}

Deshmukh, Hitesh ^{[3
,4
]}

Clair, Geremy ^{[7
]}

Kyle, Jennifer ^{[7
]}

Alexander, Laura E. Crotty ^{[8
]}

Masso-Silva, Jorge A. ^{[8
]}

Kitzmiller, Joseph A. ^{[3
]}

Wikenheiser-Brokamp, Kathryn A. ^{[3
,9
,10
]}

Deutsch, Gail ^{[11
,12
]}

Guo, Minzhe ^{[3
,4
]}

Du, Yina ^{[3
]}

Morley, Michael P. ^{[13
,14
]}

Valdez, Michael J. ^{[1
]}

Yu, Haoze, V ^{[1
]}

Jin, Kang ^{[15
,16
,17
]}

Bardes, Eric E. ^{[15
,16
,17
]}

Zepp, Jarod A. ^{[13
,18
]}

Neithamer, Terren ^{[13
,14
]}

Basil, Maria C. ^{[13
,14
]}

Zacharias, William J. ^{[3
,19
]}

Verheyden, Jamie ^{[1
]}

Young, Randee ^{[1
]}

Bandyopadhyay, Gautam ^{[6
]}

Lin, Sara ^{[20
]}

Ansong, Charles ^{[7
]}

Adkins, Joshua ^{[7
]}

Salomonis, Nathan ^{[4
,21
]}

Aronow, Bruce J. ^{[15
,16
,17
]}

Xu, Yan ^{[3
,4
]}

Pryhuber, Gloria ^{[6
]}

Whitsett, Jeff ^{[3
,4
]}

Morrisey, Edward E. ^{[13
,14
,22
]}

机构：

[1] Univ Calif San Diego, Dept Pediat, 9500 Gilman Dr, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Biol Sci, 9500 Gilman Dr, La Jolla, CA 92093 USA

[3] Cincinnati Childrens Hosp Med Ctr, Div Neonatol & Pulm Biol, 3333 Burnet Ave, Cincinnati, OH 45229 USA

[4] Univ Cincinnati, Dept Pediat, Coll Med, 3230 Eden Ave, Cincinnati, OH 45267 USA

[5] Cincinnati Childrens Hosp Med Ctr, Ctr Lung Regenerat Med, 3333 Burnet Ave, Cincinnati, OH 45229 USA

[6] Univ Rochester, Dept Pediat, Med Ctr, Div Neonatol, Rochester, NY 14642 USA

[7] Pacific Northwest Natl Lab, Biol Sci Div, Richland, WA 99352 USA

[8] Univ Calif San Diego, Dept Med, Div Pulm Crit Care & Sleep Med, La Jolla, CA 92093 USA

[9] Cincinnati Childrens Hosp Med Ctr, Div Pathol & Lab Med, 3333 Burnet Ave, Cincinnati, OH 45229 USA

[10] Univ Cincinnati, Dept Pathol & Lab Med, Coll Med, 3230 Eden Ave, Cincinnati, OH 45267 USA

[11] Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98195 USA

[12] Seattle Childrens Hosp, Dept Labs, OC 8-720,4800 Sand Point Way Northeast, Seattle, WA 98105 USA

[13] Univ Penn, Penn CHOP Lung Biol Inst, Philadelphia, PA 19104 USA

[14] Univ Penn, Dept Med, Philadelphia, PA 19104 USA

[15] Cincinnati Childrens Hosp Med Ctr, Dept Biomed Informat, Cincinnati, OH 45229 USA

[16] Cincinnati Childrens Hosp Med Ctr, Dept Dev Biol, Cincinnati, OH 45229 USA

[17] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA

[18] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA

[19] Univ Cincinnati, Dept Internal Med, Coll Med, 3230 Eden Ave, Cincinnati, OH 45267 USA

[20] NHLBI, NIH, Bldg 10, Bethesda, MD 20892 USA

[21] Cincinnati Childrens Hosp Med Ctr, Div Biomed Informat, Cincinnati, OH 45229 USA

[22] Univ Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA

来源：

DEVELOPMENTAL CELL | 2022年 / 57卷 / 01期

关键词：

INNATE LYMPHOID-CELLS; PULMONARY NEUROENDOCRINE CELLS; NEUROEPITHELIAL BODY MICROENVIRONMENT; FLOW-CYTOMETRIC ANALYSIS; CONNECTIVE-TISSUE TYPE; BASAL STEM-CELLS; ROR-GAMMA-T; SMOOTH-MUSCLE; PROGENITOR CELLS; DENDRITIC CELLS;

D O I：

10.1016/j.devcel.2021.11.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The human lung plays vital roles in respiration, host defense, and basic physiology. Recent technological advancements such as single-cell RNA sequencing and genetic lineage tracing have revealed novel cell types and enriched functional properties of existing cell types in lung. The time has come to take a new census. Initiated by members of the NHLBI-funded LungMAP Consortium and aided by experts in the lung biology community, we synthesized current data into a comprehensive and practical cellular census of the lung. Identities of cell types in the normal lung are captured in individual cell cards with delineation of function, markers, developmental lineages, heterogeneity, regenerative potential, disease links, and key experimental tools. This publication will serve as the starting point of a live, up-to-date guide for lung research at https://www.lungmap.net/cell-cards/. We hope that Lung CellCards will promote the community-wide effort to establish, maintain, and restore respiratory health.

引用

页码：112 / +

页数：37

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