The emergence of concurrent HIV-1/AIDS and visceral leishmaniasis in Northeast Brazil

被引：31

作者：

Nascimento, E. T. ^{[2
,3
]}

Moura, M. L. N. ^{[1
]}

Queiroz, J. W. ^{[3
]}

Barroso, A. W. ^{[1
]}

Araujo, A. F. ^{[4
]}

Rego, E. F. ^{[4
]}

Wilson, M. E. ^{[5
,6
,7
,8
]}

Pearson, R. D. ^{[9
,10
]}

Jeronimo, S. M. ^{[1
,3
,11
]}

机构：

[1] Univ Fed Rio Grande do Norte, Dept Biochem, Biosci Ctr, BR-59072970 Natal, RN, Brazil

[2] Univ Fed Rio Grande do Norte, Dept Infect Dis, Hlth Sci Ctr, BR-59072970 Natal, RN, Brazil

[3] Univ Fed Rio Grande do Norte, Hlth Postgrad Program, Hlth Sci Ctr, BR-59072970 Natal, RN, Brazil

[4] Hosp Giselda Trigueiro, Secretaria Estadual Saude, Natal, RN, Brazil

[5] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA

[6] Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA

[7] Univ Iowa, Dept Epidemiol, Iowa City, IA 52242 USA

[8] VA Med Ctr, Iowa City, IA USA

[9] Univ Virginia, Dept Med, Div Infect Dis & Int Hlth, Charlottesville, VA USA

[10] Univ Virginia, Dept Pathol, Div Infect Dis & Int Hlth, Charlottesville, VA USA

[11] Inst Nacl Ciencia & Tecnol Doencas Trop, Natal, RN, Brazil

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2011年 / 105卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Visceral leishmaniasis; HIV; AIDS; Leishmania chagasi; Co-infection; Brazil; HIV COINFECTION; ENDEMIC AREA; INFECTION; CHAGASI;

D O I：

10.1016/j.trstmh.2011.01.006

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

HIV has become increasingly prevalent in the Northeast region of Brazil where Leishmania infantum chagasi is endemic, and concurrent AIDS and visceral leishmaniasis (VL) has emerged. In this study, persons with HIV/AIDS and VL (n = 17) had a mean age of 37.3 years (range 29-53 years) compared with 12.5 years (1-80 years) for persons with VL alone (n = 2836). Males accounted for 88% of cases with concurrent VL and AIDS and 65% of those with VL alone. The mean CD4 count and antileishmanial antibody titre were lower and recurrence of VL and death were more likely with co-infection. Considering the prevalences of L.i. chagasi and HIV in the region, this may herald the emergence of an important public health problem. (C) 2011 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

引用

页码：298 / 300

页数：3

共 10 条

[1] HIV/AIDS-associated visceral leishmaniasis in patients from an endemic area in central-west Brazil [J].

Alexandrino-de-Oliveira, Priscilla ;

Santos-Oliveira, Joanna Reis ;

Cavalheiros Dorval, Maria Elizabeth ;

Brandao Da-Costa, Francisco das Chagas ;

Oliveira Leite Pereira, Gracy Regina ;

da Cunha, Rivaldo Venancio ;

Miranda Paniago, Anamaria Mello ;

Da-Cruz, Alda Maria .

MEMORIAS DO INSTITUTO OSWALDO CRUZ, 2010, 105 (05) :692-697

[2] A PROSPECTIVE-STUDY OF VISCERAL LEISHMANIASIS IN AN ENDEMIC AREA OF BRAZIL [J].

BADARO, R ;

JONES, TC ;

LORENCO, R ;

CERF, BJ ;

SAMPAIO, D ;

CARVALHO, EM ;

ROCHA, H ;

TEIXEIRA, R ;

JOHNSON, WD .

JOURNAL OF INFECTIOUS DISEASES, 1986, 154 (04) :639-649

[3] NEW PERSPECTIVES ON A SUBCLINICAL FORM OF VISCERAL LEISHMANIASIS [J].

BADARO, R ;

JONES, TC ;

CARVALHO, EM ;

SAMPAIO, D ;

REED, SG ;

BARRAL, A ;

TEIXEIRA, R ;

JOHNSON, WD .

JOURNAL OF INFECTIOUS DISEASES, 1986, 154 (06) :1003-1011

[4] The sensitivity and specificity of Leishmania chagasi recombinant K39 antigen in the diagnosis of American visceral leishmaniasis and in differentiating active from subclinical infection [J].

Braz, RFS ;

Nascimento, ET ;

Martins, DRA ;

Wilson, ME ;

Pearson, RD ;

Reed, SG ;

Jeronimo, SMB .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2002, 67 (04) :344-348

[5] IMMUNOLOGICAL MARKERS OF CLINICAL EVOLUTION IN CHILDREN RECENTLY INFECTED WITH LEISHMANIA-DONOVANI-CHAGASI [J].

CARVALHO, EM ;

BARRAL, A ;

PEDRALSAMPAIO, D ;

BARRALNETTO, M ;

BADARO, R ;

ROCHA, H ;

JOHNSON, WD .

JOURNAL OF INFECTIOUS DISEASES, 1992, 165 (03) :535-540

[6] VISCERAL LEISHMANIASIS EPIDEMIC IN PIAUI STATE, BRAZIL, 1980-1986 [J].

COSTA, CHN ;

PEREIRA, HF ;

ARAUJO, MV .

REVISTA DE SAUDE PUBLICA, 1990, 24 (05) :361-372

[7] CLINICAL AND EPIDEMIOLOGICAL FEATURES OF VISCERAL LEISHMANIASIS AND HIV CO-INFECTION IN FIFTEEN PATIENTS FROM BRAZIL [J].

Daher, E. F. ;

Fonseca, P. P. ;

Gerhard, E. S. ;

Silva Leitao, T. M. J. ;

Silva Junior, G. B. .

JOURNAL OF PARASITOLOGY, 2009, 95 (03) :652-655

[8] Global control and leishmania HIV co-infection [J].

Desjeux, P .

CLINICS IN DERMATOLOGY, 1999, 17 (03) :317-325

[9] AN URBAN OUTBREAK OF VISCERAL LEISHMANIASIS IN NATAL, BRAZIL [J].

JERONIMO, SMB ;

OLIVEIRA, RM ;

MACKAY, S ;

COSTA, RM ;

SWEET, J ;

NASCIMENTO, ET ;

LUZ, KG ;

FERNANDES, MZ ;

JERNIGAN, J ;

PEARSON, RD .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1994, 88 (04) :386-388

[10]

MONTALBAN C, 1989, REV INFECT DIS, V11, P655

← 1 →