Cancer stem cells

被引:0
作者
Schwarz-Cruz-y-Celis, Angela [1 ]
Melendez-Zajgla, Jorge [1 ]
机构
[1] Univ Nacl Autonoma Mexico, Unidad Genom Func Canc, Inst Nacl Med Genom, Mexico City 01900, DF, Mexico
来源
REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION | 2011年 / 63卷 / 02期
关键词
Cancer; Cancer stem cells; Self-renewal; Differentiation; Therapeutic resistance; ACUTE MYELOID-LEUKEMIA; IDENTIFICATION; MARKERS;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
There are two hypotheses that explain tumor progression. The first one, the stochastic hypothesis, assumes that any cell within a tumor has the capacity to form and maintain the tumor mass. The second, the so-called hierarchical hypothesis, suggests the existence of a group of cells with a stem phenotype which, like in normal tissues, preserves tumors through a continuous production of progeny. These stem cells are in a particular niche, have a higher resistance to chemotherapy and radiotherapy, and are also capable of invading and migrating to other tissues. This review describes the cancer stem cells (CSCs), their function inside a tumor and the current knowledge about these cells.
引用
收藏
页码:179 / 186
页数:8
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