The reactome pathway knowledgebase 2022

被引：1152

作者：

Gillespie, Marc ^{[1
,2
]}

Jassal, Bijay ^{[1
]}

Stephan, Ralf ^{[1
]}

Milacic, Marija ^{[1
]}

Rothfels, Karen ^{[1
]}

Senff-Ribeiro, Andrea ^{[1
,3
]}

Griss, Johannes ^{[4
,5
]}

Sevilla, Cristoffer ^{[4
]}

Matthews, Lisa ^{[6
]}

Gong, Chuqiao ^{[4
]}

Deng, Chuan ^{[7
,8
]}

Varusai, Thawfeek ^{[4
,9
]}

Ragueneau, Eliot ^{[4
]}

Haider, Yusra ^{[4
]}

May, Bruce ^{[1
]}

Shamovsky, Veronica ^{[6
]}

Weiser, Joel ^{[1
]}

Brunson, Timothy ^{[10
]}

Sanati, Nasim ^{[10
]}

Beckman, Liam ^{[10
]}

Shao, Xiang ^{[10
]}

Fabregat, Antonio ^{[4
]}

Sidiropoulos, Konstantinos ^{[4
]}

Murillo, Julieth ^{[11
]}

Viteri, Guilherme ^{[4
]}

Cook, Justin ^{[1
]}

Shorser, Solomon ^{[1
]}

Bader, Gary ^{[12
]}

Demir, Emek ^{[10
]}

Sander, Chris ^{[13
]}

Haw, Robin ^{[1
]}

Wu, Guanming ^{[10
]}

Stein, Lincoln ^{[1
,14
]}

Hermjakob, Henning ^{[4
,7
]}

D'Eustachio, Peter ^{[6
]}

机构：

[1] Ontario Inst Canc Res, Toronto, ON M5G 0A3, Canada

[2] St Johns Univ, Coll Pharm & Hlth Sci, Queens, NY 11439 USA

[3] Univ Fed Parana, BR-80060000 Curitiba, Parana, Brazil

[4] European Bioinformat Inst EMBL EBI, European Mol Biol Lab, Wellcome Genome Campus, Hinxton CB10 1SD, Cambs, England

[5] Med Univ Vienna, Dept Dermatol, A-1090 Vienna, Austria

[6] NYU, Grossman Sch Med, New York, NY 10016 USA

[7] Beijing Inst Life Omics, Natl Ctr Prot Sci Beijing, Beijing 102206, Peoples R China

[8] Chongqing Univ Posts & Telecommun, Chongqing Key Lab Big Data Bio Intelligence, Chongqing 400065, Peoples R China

[9] Open Targets, Wellcome Genome Campus, Hinxton CB10 1SD, Cambs, England

[10] Oregon Hlth & Sci Univ, Portland, OR 97239 USA

[11] Ctr Int Entrenamiento & Invest Med, Cali 18122135, Colombia

[12] Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada

[13] Dana Farber Canc Inst, cBio Ctr, Boston, MA 02115 USA

[14] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A1, Canada

来源：

NUCLEIC ACIDS RESEARCH | 2022年 / 50卷 / D1期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1093/nar/gkab1028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Reactome Knowledgebase (https://reactome.org), an Elixir core resource, provides manually curated molecular details across a broad range of physiological and pathological biological processes in humans, including both hereditary and acquired disease processes. The processes are annotated as an ordered network of molecular transformations in a single consistent data model. Reactome thus functions both as a digital archive of manually curated human biological processes and as a tool for discovering functional relationships in data such as gene expression profiles or somatic mutation catalogs from tumor cells. Recent curation work has expanded our annotations of normal and disease-associated signaling processes and of the drugs that target them, in particular infections caused by the SARS-CoV-1 and SARS-CoV-2 coronaviruses and the host response to infection. New tools support better simultaneous analysis of high-throughput data from multiple sources and the placement of understudied ('dark') proteins from analyzed datasets in the context of Reactome's manually curated pathways.

引用

页码：D687 / D692

页数：6

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