Signaling the glycoshield: Maintenance of the Candida albicans cell wall

被引：32

作者：

Ernst, Joachim F. ^{[1
]}

Pla, Jesus ^{[2
]}

机构：

[1] Univ Dusseldorf, Inst Mikrobiol, D-40225 Dusseldorf, Germany

[2] Univ Complutense Madrid, Fac Farm, Dept Microbiol 2, E-28040 Madrid, Spain

来源：

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2011年 / 301卷 / 05期

关键词：

Candida albicans; Glycosylation; Mannosylation; Signaling; MAPK; ACTIVATED PROTEIN-KINASE; SACCHAROMYCES-CEREVISIAE; TRANSCRIPTION FACTOR; HYPHAL DEVELOPMENT; CHITIN SYNTHESIS; DAMAGE RESPONSE; O-MANNOSYLATION; MORPHOGENESIS; VIRULENCE; PATHWAY;

D O I：

10.1016/j.ijmm.2011.04.003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In fungi, the cell wall is a scaffold, an armor and an environmental gate. Sugar polymers including protein-O- or N-linked glycosyl chains or polysaccharides such as glucan or chitin are essential components to maintain cell wall functions. We describe mechanisms in the human fungal pathogen Candida albicans, by which the integrity of glycostructures are sensed and regulated. The results stress the importance of membrane sensors and MAP kinase pathways in the maintenance of cell wall structure and function. (C) 2011 Elsevier GmbH. All rights reserved.

引用

页码：378 / 383

页数：6

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