Deconstructing iNKT cell development at single-cell resolution

被引：17
|
作者：
Baranek, Thomas [1 ]
Herbozo, Carolina de Amat [2 ]
Mallevaey, Thierry [2 ,3 ]
Paget, Christophe [1 ]
机构：
[1] Univ Tours, Inst Natl Sante Rech Med INSERM, Fac Med, Ctr Etud Pathol Resp CEPR,Unite Mixte Rech 1100, Tours, France
[2] Univ Toronto, Temerty Fac Med, Dept Immunol, Toronto, ON, Canada
[3] Univ Toronto, Inst Biomed Engn, Toronto, ON, Canada
来源：
TRENDS IN IMMUNOLOGY | 2022年 / 43卷 / 07期
基金：
加拿大创新基金会;
关键词：
KILLER T-CELLS; INVARIANT NKT CELLS; GAMMA-DELTA-T; THYMIC DIFFERENTIATION; TRANSCRIPTION FACTOR; SIGNAL STRENGTH; KAPPA-B; RECOGNITION; EXPRESSION; SUBSETS;
D O I：
10.1016/j.it.2022.04.012
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Invariant natural killer T (iNKT) cells are increasingly regarded as disease biomarkers and immunotherapeutic targets. However, a greater understanding of their biology is necessary to effectively target these cells in the clinic. The discovery of iNKT1/2/17 cell effector subsets was a milestone in our understanding of iNKT cell development and function. Recent transcriptomic studies have uncovered an even greater heterogeneity and challenge our understanding of iNKT cell ontogeny and effector differentiation. We propose a refined model whereby iNKT cells differentiate through a dynamic and continuous instructive process that requires the accumulation and integration of various signals within the thymus or peripheral tissues. Within this framework, we question the existence of true iNKT2 cells and discuss the parallels between mouse and human iNKT cells.
引用
收藏
页码：503 / 512
页数：10
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