Antinociceptive and analgesic effect of continuous intravenous infusion of maropitant, lidocaine and ketamine alone or in combination in cats undergoing ovariohysterectomy

被引:6
|
作者
Xavier Correa, Janaina Maria [1 ]
Niella, Raquel Vieira [1 ]
Silva de Oliveira, Jessica Natalia [1 ]
Silva Junior, Alex Costa [1 ]
da Costa Marques, Claire Souza [1 ]
Pinto, Taisa Miranda [1 ]
da Silva, Elisangela Barboza [1 ]
Beier, Suzane Lilian [2 ]
Silva, Fabiana Lessa [1 ]
Lima de Lavor, Mario Sergio [1 ]
机构
[1] State Univ Santa Cruz UESC, Dept Agr & Environm Sci, Campus Soane Nazare de Andrade,Km 16, BR-45662900 Ilheus, BA, Brazil
[2] Univ Fed Minas Gerais, Sch Vet Med, Campus Pampulha,Ave Antonio Carlos 6627, Belo Horizonte, MG, Brazil
关键词
NK1 receptor antagonist; N-methyl-d-aspartate; Neurokinin; 1; Pain; Sodium channels; MINIMUM ALVEOLAR CONCENTRATION; CONSTANT-RATE-INFUSION; RECEPTOR ANTAGONIST; POSTOPERATIVE ANALGESIA; OVARIAN LIGAMENT; PAIN MANAGEMENT; ISOFLURANE; DOGS; SEVOFLURANE; DEXMEDETOMIDINE;
D O I
10.1186/s13028-021-00615-w
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Background Multimodal analgesia consists of the combination of analgesic drugs at low doses to act in different places along the path of pain. Studies with continuous infusion of analgesic drugs in cats are not common. This study aimed to evaluate the analgesic effect of maropitant, lidocaine and ketamine alone or in combination (intravenous bolus + subsequent continuous intravenous infusion) in the management of acute postoperative pain in cats undergoing ovariohysterectomy. Seventy healthy cats undergoing an ovariohysterectomy received a standard anesthetic protocol consisting of acepromazine and morphine, propofol (anesthesia induction), and isoflurane (anesthesia maintenance). The animals were stratified into seven groups (n = 10 in each group): control (CG), maropitant (MG), lidocaine (LG), ketamine (KG), maropitant + lidocaine (LMG), maropitant + ketamine (KMG), and maropitant + lidocaine + ketamine (LKMG). All drugs were injected first as an intravenous bolus and then by continuous intravenous infusion. During surgery, esophageal temperature, respiratory rate, heart rate, oxygen saturation, expired isoflurane concentration, and partial pressure of carbon dioxide at the end of expiration were evaluated at 7 time points. Postoperative pain was evaluated for 6 h after extubation using the visual analogue scale and the UNESP-Botucatu multidimensional composite pain scale for assessing postoperative pain in cats. Results Adverse effects related to maropitant, lidocaine and ketamine infusion were not observed. Pain scores were lower in the MG, KG and LG groups when compared to the CG group using both scales. Although pain scores were also lower in all combination groups than CG, more animals in these groups required rescue analgesia compared to MG. This indicates that the postoperative analgesic effect of all drugs, either alone or in combination, confers analgesia, although the combinations did not promote greater analgesia. Conclusions Continuous intravenous infusion of maropitant, lidocaine, and ketamine alone induces postoperative analgesic effect in cats undergoing ovariohysterectomy, but combinations of these drugs did not increase the analgesic effect. No adverse effect was observed with any drug or their combination.
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页数:8
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