DOSY Analysis of Micromolar Analytes: Resolving Dilute Mixtures by SABRE Hyperpolarization

被引：26

作者：

Reile, Indrek ^{[1
]}

Aspers, Ruud L. E. G. ^{[1
]}

Tyburn, Jean-Max ^{[2
]}

Kempf, James G. ^{[3
]}

Feiters, Martin C. ^{[1
]}

Rutjes, Floris P. J. T. ^{[1
]}

Tessari, Marco ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Inst Mol & Mat, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands

[2] Bruker BioSpin GmbH, Silberstreifen, Rheinstetten, Germany

[3] Bruker Biospin Corp, Billerica, MA 01821 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 31期

关键词：

DOSY; hyperpolarization; NMR spectroscopy; parahydrogen; SABRE; DIFFUSION-ORDERED SPECTROSCOPY; FIELD GRADIENT NMR; LIQUID-STATE NMR; REVERSIBLE EXCHANGE; PARA-HYDROGEN; SIGNAL AMPLIFICATION; POLARIZATION; CONVECTION; EXTRACTS; DESIGN;

D O I：

10.1002/anie.201703577

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

DOSY is an NMR spectroscopy technique that resolves resonances according to the analytes' diffusion coefficients. It has found use in correlating NMR signals and estimating the number of components in mixtures. Applications of DOSY in dilute mixtures are, however, held back by excessively long measurement times. We demonstrate herein, how the enhanced NMR sensitivity provided by SABRE hyperpolarization allows DOSY analysis of low-micromolar mixtures, thus reducing the concentration requirements by at least 100-fold.

引用

页码：9174 / 9177

页数：4

共 8 条

[1] Quantitative Trace Analysis of Complex Mixtures Using SABRE Hyperpolarization
Eshuis, Nan
van Weerdenburg, Bram J. A.
Feiters, Martin C.
Rutjes, Floris P. J. T.
Wijmenga, Sybren S.
Tessari, Marco
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015, 54 (05) : 1481 - 1484
[2] Single-Scan Multidimensional NMR Analysis of Mixtures at Sub-Millimolar Concentrations by using SABRE Hyperpolarization
Daniele, Valeria
Legrand, Francois-Xavier
Berthault, Patrick
Dumez, Jean-Nicolas
Huber, Gaspard
CHEMPHYSCHEM, 2015, 16 (16) : 3413 - 3417
[3] Trace analysis in water-alcohol mixtures by continuous p-H2 hyperpolarization at high magnetic field
Hermkens, Niels K. J.
Aspers, Ruud L. E. G.
Feiters, Martin C.
Rutjes, Floris P. J. T.
Tessari, Marco
MAGNETIC RESONANCE IN CHEMISTRY, 2018, 56 (07) : 633 - 640
[4] Analysis of Complex Mixtures by Chemosensing NMR Using para-Hydrogen-Induced Hyperpolarization
Fraser, Roan
Rutjes, Floris P. J. T.
Feiters, Martin C.
Tessari, Marco
ACCOUNTS OF CHEMICAL RESEARCH, 2022, : 1832 - 1844
[5] Utilization of SABRE-Derived Hyperpolarization To Detect Low-Concentration Analytes via 1D and 2D NMR Methods
Lloyd, Lyrelle S.
Adams, Ralph W.
Bernstein, Michael
Coombes, Steven
Duckett, Simon B.
Green, Gary G. R.
Lewis, Richard. J.
Mewis, Ryan E.
Sleigh, Christopher J.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (31) : 12904 - 12907
[6] Matrix-Assisted DOSY for Analysis of Indole Alkaloid Mixtures
You, Yu-Lin
Li, Fei-Fei
Wang, Ning
Wang, Shu-Qi
MOLECULES, 2021, 26 (06):
[7] A three-dimensional DOSY-HMQC experiment for the high-resolution analysis of complex mixtures
Barjat, H
Morris, GA
Swanson, AG
JOURNAL OF MAGNETIC RESONANCE, 1998, 131 (01) : 131 - 138
[8] Independent component analysis applied to diffusion-ordered spectroscopy: separating nuclear magnetic resonance spectra of analytes in mixtures
Zhong, J.
DiDonato, N.
Hatcher, P. G.
JOURNAL OF CHEMOMETRICS, 2012, 26 (05) : 150 - 157

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