Synthesis and Structures of Halo-Substituted Aroylhydrazones with Antimicrobial Activity

被引：168

作者：

Zhang, Mei ^{[1
]}

Xian, Dong-Mei ^{[1
]}

Li, Hai-Hua ^{[1
]}

Zhang, Ji-Cai ^{[1
]}

You, Zhong-Lu ^{[1
]}

机构：

[1] Liaoning Normal Univ, Dept Chem & Chem Engn, Dalian 116029, Peoples R China

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2012年 / 65卷 / 04期

关键词：

ANTIBACTERIAL ACTIVITIES; CRYSTAL-STRUCTURES; CYTOTOXIC ACTIVITIES; SCHIFF-BASES; HYDRAZONE; COMPLEXES; DERIVATIVES; COPPER(II); ZINC(II); DESIGN;

D O I：

10.1071/CH11424

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of new halo-substituted aroylhydrazones have been prepared and structurally characterized by elemental analysis, H-1 NMR, C-13 NMR, and IR spectra, and single crystal X-ray diffraction. The compounds were evaluated for their antibacterial (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas fluorescence) and antifungal (Candida albicans and Aspergillus niger) activities by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. Among the tested compounds, N'-(2-chloro-5-nitrobenzylidene)-2-fluorobenzohydrazide showed the most effective antimicrobial activity with minimum inhibitory concentration values of 0.82, 2.5, 1.7, 15.2, and 37.5 mu g mL(-1) against B. subtilis, S. aureus, E. coli, P. fluorescence, and C. albicans, respectively. The biological assay indicated that the presence of the electron-withdrawing groups in the aroylhydrazones improved their antimicrobial activities.

引用

页码：343 / 350

页数：8

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