A ternary supramolecular system containing a boronated DNA-metallointercalator, β-cyclodextrin and the hexanucleotide d(GTCGAC)2

被引：11

作者：

Ching, H. Y. Vincent ^{[1
]}

Buck, Damian P. ^{[2
]}

Bhadbhade, Mohan ^{[3
]}

Collins, J. Grant ^{[2
]}

Rendina, Louis M. ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

[2] Univ New S Wales, Australian Def Force Acad, Univ Coll, Sch Phys Environm & Math Sci, Canberra, ACT 2600, Australia

[3] Univ New S Wales, Solid State & Elemental Anal Unit, Sydney, NSW 2052, Australia

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 06期

基金：

澳大利亚研究理事会;

关键词：

NEUTRON-CAPTURE THERAPY; GAMMA-CYCLODEXTRIN; COMPLEX; BINDING; INTERCALATION; CYTOTOXICITY; RECOGNITION; CARBORANE;

D O I：

10.1039/c1cc15552k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Solution NMR studies of the interaction between the hexanucleotide d(GTCGAC)(2), beta-cyclodextrin and a boronated 2,2':6',2 ''-terpyridineplatinum(II) complex containing 1,12-dicarba-closo-dodecaborane(12) (1,12-closo-carborane) reveal the formation of a remarkable ternary supramolecular system in which the terpyridine ligand is intercalated between the C-3 and G(4) bases, whilst the closo-carborane moiety is encapsulated by the cyclic sugar.

引用

页码：880 / 882

页数：3

共 29 条

[1] Cyclodextrins as pharmaccutical solubilizers [J].

Brewster, Marcus E. ;

Loftsson, Thorsteinn .

ADVANCED DRUG DELIVERY REVIEWS, 2007, 59 (07) :645-666

[2] Cyclodextrin-based bioactive supramolecular assemblies [J].

Chen, Yong ;

Liu, Yu .

CHEMICAL SOCIETY REVIEWS, 2010, 39 (02) :495-505

[3] Interaction of [Pt(en)(phen)]2+ and [Pt(en)(phi)]2+ with the hexanucleotide d(GTCGAC)2:: Evidence for minor groove binding [J].

Collins, JG ;

Rixon, RM ;

Aldrich-Wright, JR .

INORGANIC CHEMISTRY, 2000, 39 (19) :4377-4379

[4] H-1-NMR OF RH(NH3)(4)PHI(3+) BOUND TO D(TGGCCA)(2) - CLASSICAL INTERCALATION BY A NONCLASSICAL OCTAHEDRAL METALLOINTERCALATOR [J].

COLLINS, JG ;

SHIELDS, TP ;

BARTON, JK .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (22) :9840-9846

[5]

Crossley E. L., 2011, BIOINORGANIC MED CHE, P283

[6] A highly water-soluble platinum(II) complex containing a thiopropyl-1,2-dicarba-closo-dodecaborane(12) ligand functionalised with a pendant glycerol group [J].

Crossley, EL ;

Caiazza, D ;

Rendina, LM .

DALTON TRANSACTIONS, 2005, (17) :2825-2826

[7] Boronated DNA-binding compounds as potential agents for boron neutron capture therapy [J].

Crossley, Ellen L. ;

Ziolkowski, Erin J. ;

Coderre, Jeffrey A. ;

Rendina, Louis M. .

MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2007, 7 (03) :303-313

[8] NMR EVIDENCE FOR SPECIFIC INTERCALATION OF DELTA-RH(PHEN)2PHI3+ IN [D(GTCGAC)2] [J].

DAVID, SS ;

BARTON, JK .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (07) :2984-2985

[9]

Dodziuk H., 2006, CYCLODEXTRIN THEIR C

[10]

Easton C.J., 1999, MODIFIED CYCLODEXTRI

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