Hypoxia and tumor angiogenesis in the era of hepatocellular carcinoma transarterial loco-regional treatments

被引：71

作者：

Petrillo, Mario ^{[1
]}

Patella, Francesca ^{[2
]}

Pesapane, Filippo ^{[2
]}

Suter, Matteo B. ^{[3
]}

Ierardi, Anna M. ^{[1
]}

Angileri, Salvatore A. ^{[1
]}

Floridi, Chiara ^{[4
]}

de Filippo, Massimo ^{[5
]}

Carrafiello, Gianpaolo ^{[1
]}

机构：

[1] San Paolo Hosp, Diagnost & Intervent Radiol Serv, Milan, Italy

[2] Postgrad Sch Radiodiagnost Milan, Dept Hlth Sci, Milan, Italy

[3] ASST Sette Laghi, Dept Med Oncol, Varese, Italy

[4] Fatebenefratelli Hosp, Dept Diagnost & Intervent Radiol, Milan, Italy

[5] Univ Parma, Azienda Osped, Dept Med & Surg, Via Gramsci, Parma 14, Italy

来源：

FUTURE ONCOLOGY | 2018年 / 14卷 / 28期

关键词：

embolotherapy; HCC; hypoxia; individualized treatment; neoangiogenesis; sorafenib; TACE; TAE; TARE; VEGF; TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION; ENDOTHELIAL GROWTH-FACTOR; DEGRADABLE STARCH MICROSPHERES; Y-90; RADIOEMBOLIZATION; LIVER-TRANSPLANTATION; SORAFENIB; TACE; VEGF; RADIOTHERAPY; EMBOLIZATION;

D O I：

10.2217/fon-2017-0739

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This review focuses upon interactions and potential therapeutic targets in the vicious cycle' between hypoxia and neoangiogenesis following treatment of hepatocellular carcinoma with transarterial loco-regional therapies. Biomarkers correlated with angiogenesis have been studied by many authors as prognostic determinants following transarterial intrahepatic therapy. According to these results future therapies directed toward specific factors related to angiogenesis could play a significant role in preventing local tumor recurrence and remote metastasis.

引用

页码：2957 / 2967

页数：12

共 69 条

[1]

[Anonymous], 2017, LANCET, DOI DOI 10.1016/S0140-6736(17)32152-9

[2]

[Anonymous], DIG LIV DIS 45S 46 A

[3]

[Anonymous], CLIN GASTROENTEROL H

[4] The role of 90Y-radioembolization in downstaging primary and secondary hepatic malignancies: a systematic review [J].

Braat M.N.G.J.A. ;

Samim M. ;

van den Bosch M.A.A.J. ;

Lam M.G.E.H. .

Clinical and Translational Imaging, 2016, 4 (4) :283-295

[5] Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer [J].

Brahmer, Julie ;

Reckamp, Karen L. ;

Baas, Paul ;

Crino, Lucio ;

Eberhardt, Wilfried E. E. ;

Poddubskaya, Elena ;

Antonia, Scott ;

Pluzanski, Adam ;

Vokes, Everett E. ;

Holgado, Esther ;

Waterhouse, David ;

Ready, Neal ;

Gainor, Justin ;

Aren Frontera, Osvaldo ;

Havel, Libor ;

Steins, Martin ;

Garassino, Marina C. ;

Aerts, Joachim G. ;

Domine, Manuel ;

Paz-Ares, Luis ;

Reck, Martin ;

Baudelet, Christine ;

Harbison, Christopher T. ;

Lestini, Brian ;

Spigel, David R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (02) :123-135

[6] Abscopal, immunological effects of radiotherapy: Narrowing the gap between clinical and preclinical experiences [J].

Brix, Nikko ;

Tiefenthaller, Anna ;

Anders, Heike ;

Belka, Claus ;

Lauber, Kirsten .

IMMUNOLOGICAL REVIEWS, 2017, 280 (01) :249-279

[7] Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial [J].

Bruix, Jordi ;

Qin, Shukui ;

Merle, Philippe ;

Granito, Alessandro ;

Huang, Yi-Hsiang ;

Bodoky, Gyrogy ;

Pracht, Marc ;

Yokosuka, Osamu ;

Rosmorduc, Olivier ;

Breder, Valeriy ;

Gerolami, Rene ;

Masi, Gianluca ;

Ross, Paul J. ;

Song, Tianqiang ;

Bronowicki, Jean-Pierre ;

Ollivier-Hourmand, Isabelle ;

Kudo, Masatoshi ;

Cheng, Ann-Lii ;

Llovet, Josep M. ;

Finn, Richard S. ;

LeBerre, Marie-Aude ;

Baumhauer, Annette ;

Meinhardt, Gerold ;

Han, Guohong .

LANCET, 2017, 389 (10064) :56-66

[8] Pilot Study of Angiogenic Response to Yttrium-90 Radioembolization with Resin Microspheres [J].

Carpizo, Darren R. ;

Gensure, Rebekah H. ;

Yu, Xin ;

Gendel, Vyacheslav M. ;

Greene, Samuel J. ;

Moore, Dirk F. ;

Jabbour, Salma K. ;

Nosher, John L. .

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 2014, 25 (02) :297-306

[9] Decreased Incidence of Hepatocellular Carcinoma in Hepatitis B Vaccinees: A 20-Year Follow-up Study [J].

Chang, Mei-Hwei ;

You, San-Lin ;

Chen, Chien-Jen ;

Liu, Chun-Jen ;

Lee, Chuan-Mo ;

Lin, Shi-Ming ;

Chu, Heng-Cheng ;

Wu, Tzee-Chung ;

Yang, Sheng-Shun ;

Kuo, Hsu-Sung ;

Chen, Ding-Shinn .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2009, 101 (19) :1348-1355

[10] Cytokines are associated with postembolization fever and survival in hepatocellular carcinoma patients receiving transcatheter arterial chemoembolization [J].

Chao, Yee ;

Wu, Chen-Yi ;

Kuo, Chen-Yu ;

Wang, Jack P. ;

Luo, Jiing-Chyuan ;

Kao, Chien-Hui ;

Lee, Rheun-Chuan ;

Lee, Wei-Ping ;

Li, Chung-Pin .

HEPATOLOGY INTERNATIONAL, 2013, 7 (03) :883-892

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