Gait Performance in Hypertensive Patients on Angiotensin-Converting Enzyme Inhibitors

被引：15

作者：

George, Claudene J. ^{[1
]}

Verghese, Joe ^{[2
]}

机构：

[1] Montefiore Med Ctr, Albert Einstein Coll Med, Div Geriatr, 111 East 210th St, Bronx, NY 10467 USA

[2] Albert Einstein Coll Med, Div Cognit & Motor Aging & Geriatr, Bronx, NY 10467 USA

来源：

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION | 2016年 / 17卷 / 08期

关键词：

Ace inhibitors; physical performance; gait; PHYSICAL FUNCTION; OLDER-ADULTS; MUSCLE STRENGTH; DEMENTIA; DECLINE; WOMEN; RISK; IMPAIRMENT; MARKERS; TRIAL;

D O I：

10.1016/j.jamda.2016.03.022

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Objective: To examine the relationship between angiotensin-converting enzyme inhibitor (ACEI) use and gait performance in older adults. Design: Cross-sectional survey. Setting: Community. Participants: A total of 281 community-dwelling older adults with hypertension enrolled in an aging study. Measurements: Quantitative variables used to define gait performance included velocity (cm/s), stride length (cm), swing time (s), stride length variability (SD), and swing time variability (SD). Results: There were 72 hypertensive participants on ACEIs and 209 were on other antihypertensive medications. Linear regression analysis adjusted for age, sex, and potential confounders revealed that hypertensive participants on an ACEI walked 7.29 cm/s slower (P = .016) and stride length was 6.86 cm shorter (P = .006) compared with those not on ACEIs. There were no significant differences on the other gait variables examined. Conclusion: ACEI use was associated with worse gait performance in elderly hypertensives. Biological mechanisms need to be explored, and clinicians should consider monitoring gait speed in hypertensive patients on ACEIs. (C) 2016 AMDA - The Society for Post-Acute and Long-Term Care Medicine.

引用

页码：737 / 740

页数：4

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