Peritoneal Immune System in Patients with Advance Epithelial Ovarian Cancer

被引:12
|
作者
Wertel, Iwona [1 ]
Nowicka, Aldona [1 ]
Rogala, Ewelina [1 ]
Kotarski, Jan [1 ]
机构
[1] Med Univ, Chair & Dept Oncol Gynaecol & Gynaecol 1, PL-20950 Lublin, Poland
关键词
ovarian cancer; peritoneal cavity; dendritic cells; tumor-infiltrating cells; ENDOTHELIAL GROWTH-FACTOR; REGULATORY T-CELLS; TUMOR-INFILTRATING LYMPHOCYTES; PLASMACYTOID DENDRITIC CELLS; SUPPRESSOR-CELLS; PERIPHERAL-BLOOD; ASCITIC FLUID; IMMUNOSUPPRESSIVE NETWORKS; PROGNOSTIC-SIGNIFICANCE; VASCULAR LEUKOCYTES;
D O I
10.3109/08830185.2011.569902
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The development of epithelial ovarian cancer is associated with changes in the peritoneal cavity microenvironment. Tumor cells produce different factors, which impairs differentiation, maturation, and function of antigen-presenting cells. In this review, we focus on selected cell populations in the peritoneal cavity immune system and their potential role in epithelial ovarian cancer immunopathogenesis. We devote most attention to dendritic cells because they are considered to be superior in their antigen-presenting ability, compared with both macrophages and B lymphocytes. We also present a brief characterization of tumor-infiltraiting cells in epithelial ovarian cancer patients.
引用
收藏
页码:87 / 101
页数:15
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