Hepatocellular Carcinoma Arising in a Pigmented Telangiectatic Adenoma With Nuclear β-catenin and Glutamine Synthetase Positivity: Case Report and Review of the Literature

被引：27

作者：

Hechtman, Jaclyn F. ^{[1
]}

Raoufi, Mohammad ^{[1
]}

Fiel, M. Isabel ^{[1
]}

Taouli, Bachir ^{[2
]}

Facciuto, Marcelo ^{[3
]}

Schiano, Thomas D. ^{[4
]}

Blouin, Amanda G. ^{[1
]}

Thung, Swan N. ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Dept Pathol, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Dept Radiol, New York, NY 10029 USA

[3] Mt Sinai Sch Med, Dept Surg, New York, NY 10029 USA

[4] Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA

来源：

AMERICAN JOURNAL OF SURGICAL PATHOLOGY | 2011年 / 35卷 / 06期

关键词：

telangiectatic adenoma; hepatocellular carcinoma; hepatocellular adenoma; telangiectatic hepatocellular adenoma; pigmented hepatocellular adenoma; beta-catenin; glutamine synthetase; Dubin-Johnson pigment; FOCAL NODULAR HYPERPLASIA; LIVER-CELL ADENOMA; MALIGNANT-TRANSFORMATION; SUBTYPE CLASSIFICATION; PATHOLOGY; MARKERS;

D O I：

10.1097/PAS.0b013e318218ca3f

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Telangiectatic hepatocellular adenoma is a rare, recently recognized subtype of hepatocellular adenoma that is often underrecognized by pathologists. We report a case of hepatocellular carcinoma arising within a pigmented telangiectatic hepatocellular adenoma in a noncirrhotic man with diffuse glutamine synthetase and nuclear beta-catenin positivity. This case highlights malignant transformation of telangiectatic adenomas, and describes a previously unreported association between pigment deposition and telangiectatic adenoma. Radiology, gross pathology, and histopathology are shown. Review of the literature with attention to beta-catenin and glutamine synthetase staining, malignant transformation, patient characteristics, the presence of Dubin-Johnson-like pigment, and genetic characteristics of telangiectatic adenomas are discussed.

引用

页码：927 / 932

页数：6

共 24 条

[1]

Bancroft J.D., 2001, Theory and Practice of Histological Techniques

[2] Multiple black hepatocellular adenomas in a male patient [J].

Bernard, PH ;

Blanc, JF ;

Paulusma, C ;

Le Bail, B ;

Carles, J ;

Balabaud, C ;

Bioulac-Sage, P .

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2000, 12 (11) :1253-1257

[3] Clinical, morphologic, and molecular features defining so-called telangiectatic focal nodular hyperplasias of the liver [J].

Bioulac-Sage, P ;

Rebouissou, S ;

Cunha, AS ;

Jeannot, E ;

Lepreux, S ;

Blanc, JF ;

Blanché, H ;

Le Bail, B ;

Saric, J ;

Laurent-Puig, P ;

Balabaud, C ;

Zucman-Rossi, J .

GASTROENTEROLOGY, 2005, 128 (05) :1211-1218

[4] Hepatocellular adenoma subtype classification using molecular markers and lmmunohistochemistry [J].

Bioulac-Sage, Paulette ;

Rebouissou, Sandra ;

Thomas, Cristel ;

Blanc, Jean-Frederic ;

Saric, Jean ;

Cunha, Antonio Sa ;

Ruiller, Anne ;

Cubel, Gaeelle ;

Couchy, Gabrielle ;

Imbeaud, Sandrine ;

Balabaud, Charles ;

Zucman-Rossi, Jessica .

HEPATOLOGY, 2007, 46 (03) :740-748

[5] Revisiting the Pathology of Resected Benign Hepatocellular Nodules Using New Immunohistochemical Markers [J].

Bioulac-Sage, Paulette ;

Cubel, Gaelle ;

Balabaud, Charles ;

Zucman-Rossi, Jessica .

SEMINARS IN LIVER DISEASE, 2011, 31 (01) :91-103

[6] Subtype Classification of Hepatocellular Adenoma [J].

Bioulac-Sage, Paulette ;

Balabaud, Charles ;

Zucman-Rossi, Jessica .

DIGESTIVE SURGERY, 2010, 27 (01) :39-45

[7] Hepatocellular carcinoma in a liver-cell adenoma within a non-cirrhotic liver [J].

Burri, Emanuel ;

Steuerwald, Michael ;

Cathomas, Gieri ;

Mentha, Gilles ;

Majno, Pietro ;

Rubbia-Brandt, Laura ;

Meier, Remy .

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2006, 18 (04) :437-441

[8] A Single-Center Surgical Experience of 122 Patients With Single and Multiple Hepatocellular Adenomas [J].

Dokmak, Safi ;

Paradis, Valerie ;

Vilgrain, Valerie ;

Sauvanet, Alain ;

Farges, Olivier ;

Valla, Dominique ;

Bedossa, Pierre ;

Belghiti, Jacques .

GASTROENTEROLOGY, 2009, 137 (05) :1698-1705

[9] Malignant Transformation of Liver Adenoma: An Analysis of the Literature [J].

Farges, Olivier ;

Dokmak, Safi .

DIGESTIVE SURGERY, 2010, 27 (01) :32-38

[10]

Ferko A, 2003, Rozhl Chir, V82, P192

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