Polyhalogenated benzo- and naphthoquinones are potent inhibitors of plant and bacterial ureases

被引：26

作者：

Ashiralieva, A ^{[1
]}

Kleiner, D ^{[1
]}

机构：

[1] Univ Bayreuth, D-95440 Bayreuth, Germany

来源：

FEBS LETTERS | 2003年 / 555卷 / 02期

关键词：

urease; enzyme inhibition; quinone; fluoranil; chloranil; bromanil;

D O I：

10.1016/S0014-5793(03)01289-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polyhalogenated benzo- and naphthoquinones were found to be potent inhibitors of pure ureases from Bacillus pasteurii and Canavalia ensiformis. They also inhibited ureases in whole cells of Helicobacter pylori, Klebsiella oxytoca and Proteus mirabilis. Inhibition was non-competitive with K-i values in the micromolar range or below. Inhibition was irreversible as shown by equilibrium dialysis. Inhibitory power decreased considerably when halogens were replaced by -OH, -CN, alkoxy or alkyl groups. (C) 2003 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：367 / 370

页数：4

共 27 条

[1] Chemistry and mechanism of urease inhibition [J].