The role of mitochondria in the pathophysiology and treatment of common metabolic diseases in humans

被引：20
作者：
Georgiev, Asen [1 ,2 ]
Granata, Cesare [1 ,2 ,3 ,4 ]
Roden, Michael [1 ,2 ,5 ,6 ]
机构：
[1] Heinrich Heine Univ Dusseldorf, German Diabet Ctr, Inst Clin Diabetol, Leibniz Ctr Diabet Res, Dusseldorf, Germany
[2] German Ctr Diabet Res, Partner Dusseldorf, Munich, Germany
[3] Monash Univ, Cent Clin Sch, Dept Diabet, Melbourne, Vic, Australia
[4] Victoria Univ, Inst Hlth & Sport iHeS, Melbourne, Vic, Australia
[5] Heinrich Heine Univ Dusseldorf, Med Fac, Dept Endocrinol & Diabetol, Dusseldorf, Germany
[6] Heinrich Heine Univ Dusseldorf, Univ Hosp Dusseldorf, Dusseldorf, Germany
来源：
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | 2022年 / 322卷 / 06期
关键词：
adipose tissue; mitophagy; oxidative phosphorylation; skeletal muscle; steatosis; NONALCOHOLIC FATTY LIVER; SKELETAL-MUSCLE; OXIDATIVE-PHOSPHORYLATION; INSULIN-RESISTANCE; ADIPOSE-TISSUE; OBESE; RESPIRATION; HOMEOSTASIS; STEATOHEPATITIS; SPECTROSCOPY;
D O I：
10.1152/ajpcell.00035.2022
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Common metabolic diseases such as obesity, type 2 diabetes mellitus, and nonalcoholic fatty liver disease significantly contribute to morbidity and mortality worldwide. They are frequently associated with insulin resistance and altered mitochondrial functionality. Insulin-responsive tissues can show changes in mitochondrial features such as oxidative capacity, mitochondrial content, and turnover, which do not necessarily reflect abnormalities but rather adaptation to a certain metabolic condition. Lifestyle modifications and classic or novel drugs can modify these alterations and help to treat these metabolic diseases. This review addresses the role of mitochondria in human metabolic diseases and discusses potential future research directions.
引用
收藏
页码：C1248 / C1259
页数：12
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