The role of mitochondria in the pathophysiology and treatment of common metabolic diseases in humans

被引：20
作者：
Georgiev, Asen [1 ,2 ]
Granata, Cesare [1 ,2 ,3 ,4 ]
Roden, Michael [1 ,2 ,5 ,6 ]
机构：
[1] Heinrich Heine Univ Dusseldorf, German Diabet Ctr, Inst Clin Diabetol, Leibniz Ctr Diabet Res, Dusseldorf, Germany
[2] German Ctr Diabet Res, Partner Dusseldorf, Munich, Germany
[3] Monash Univ, Cent Clin Sch, Dept Diabet, Melbourne, Vic, Australia
[4] Victoria Univ, Inst Hlth & Sport iHeS, Melbourne, Vic, Australia
[5] Heinrich Heine Univ Dusseldorf, Med Fac, Dept Endocrinol & Diabetol, Dusseldorf, Germany
[6] Heinrich Heine Univ Dusseldorf, Univ Hosp Dusseldorf, Dusseldorf, Germany
来源：
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | 2022年 / 322卷 / 06期
关键词：
adipose tissue; mitophagy; oxidative phosphorylation; skeletal muscle; steatosis; NONALCOHOLIC FATTY LIVER; SKELETAL-MUSCLE; OXIDATIVE-PHOSPHORYLATION; INSULIN-RESISTANCE; ADIPOSE-TISSUE; OBESE; RESPIRATION; HOMEOSTASIS; STEATOHEPATITIS; SPECTROSCOPY;
D O I：
10.1152/ajpcell.00035.2022
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Common metabolic diseases such as obesity, type 2 diabetes mellitus, and nonalcoholic fatty liver disease significantly contribute to morbidity and mortality worldwide. They are frequently associated with insulin resistance and altered mitochondrial functionality. Insulin-responsive tissues can show changes in mitochondrial features such as oxidative capacity, mitochondrial content, and turnover, which do not necessarily reflect abnormalities but rather adaptation to a certain metabolic condition. Lifestyle modifications and classic or novel drugs can modify these alterations and help to treat these metabolic diseases. This review addresses the role of mitochondria in human metabolic diseases and discusses potential future research directions.
引用
收藏
页码：C1248 / C1259
页数：12
相关论文
共 120 条
[1]   The characterisation of hepatic mitochondrial function in patients with non-alcoholic fatty liver disease (NAFLD) using the 13C-ketoisocaproate breath test [J].
Afolabi, Paul R. ;
Scorletti, Eleonora ;
Smith, Debbie E. ;
Almehmadi, Amal A. ;
Calder, Philip C. ;
Byrne, Christopher D. .
JOURNAL OF BREATH RESEARCH, 2018, 12 (04)
[2]   Phenotypic and Genetic Characteristics of Lipodystrophy: Pathophysiology, Metabolic Abnormalities, and Comorbidities [J].
Akinci, Baris ;
Meral, Rasimcan ;
Oral, Elif Arioglu .
CURRENT DIABETES REPORTS, 2018, 18 (12)
[3]   Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients [J].
Anello, M ;
Lupi, R ;
Spampinato, D ;
Piro, S ;
Masini, M ;
Boggi, U ;
Del Prato, S ;
Rabuazzo, AM ;
Purrello, F ;
Marchetti, P .
DIABETOLOGIA, 2005, 48 (02) :282-289
[4]  
Apostolopoulou M, SCI
[5]   Role of ceramide-to-dihydroceramide ratios for insulin resistance and non-alcoholic fatty liver disease in humans [J].
Apostolopoulou, Maria ;
Gordillo, Ruth ;
Gancheva, Sofiya ;
Strassburger, Klaus ;
Herder, Christian ;
Esposito, Irene ;
Schlensak, Matthias ;
Scherer, Philipp E. ;
Roden, Michael .
BMJ OPEN DIABETES RESEARCH & CARE, 2020, 8 (02)
[6]   Adipose Tissue-Liver Cross Talk in the Control of Whole-Body Metabolism: Implications in Nonalcoholic Fatty Liver Disease [J].
Azzu, Vian ;
Vacca, Michele ;
Virtue, Samuel ;
Allison, Michael E. D. ;
Vidal-Puig, Antonio .
GASTROENTEROLOGY, 2020, 158 (07) :1899-1912
[7]   Reduced Respiratory Capacity in Muscle Mitochondria of Obese Subjects [J].
Bakkman, Linda ;
Fernstrom, Maria ;
Loogna, Peter ;
Rooyackers, Olav ;
Brandt, Lena ;
Lagerros, Ylva Trolle .
OBESITY FACTS, 2010, 3 (06) :371-375
[8]   Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy [J].
Befroy, Douglas E. ;
Perry, Rachel J. ;
Jain, Nimit ;
Dufour, Sylvie ;
Cline, Gary W. ;
Trimmer, Jeff K. ;
Brosnan, Julia ;
Rothman, Douglas L. ;
Petersen, Kitt Falk ;
Shulman, Gerald I. .
NATURE MEDICINE, 2014, 20 (01) :98-+
[9]   Alterations in Mitochondrial Oxidative Stress and Mitophagy in Subjects With Prediabetes and Type 2 Diabetes Mellitus [J].
Bhansali, Shipra ;
Bhansali, Anil ;
Walia, Rama ;
Saikia, Uma Nahar ;
Dhawan, Veena .
FRONTIERS IN ENDOCRINOLOGY, 2017, 8
[10]   Mechanisms of mitophagy: PINK1, Parkin, USP30 and beyond [J].
Bingol, Baris ;
Sheng, Morgan .
FREE RADICAL BIOLOGY AND MEDICINE, 2016, 100 :210-222
12345678910