Gliadin-reactive vitamin D-sensitive proinflammatory ILCPs are enriched in celiac patients

被引：9

作者：

Ercolano, Giuseppe ^{[5
]}

Moretti, Alex ^{[2
,6
]}

Falquet, Maryline ^{[1
,7
,8
]}

Wyss, Tania ^{[1
]}

Tran, Ngoc Lan ^{[1
,3
]}

Senoner, Isis ^{[3
]}

Marinoni, Maddalena ^{[2
,4
]}

Agosti, Massimo ^{[2
]}

Salvatore, Silvia ^{[2
]}

Jandus, Camilla ^{[1
,7
,8
]}

Trabanelli, Sara ^{[1
,7
,8
]}

机构：

[1] Univ Lausanne, Ludwig Inst Canc Res, UNIL CHUV, Dept Oncol, CH-1066 Lausanne, Switzerland

[2] Univ Insubria, Hosp F Ponte, Pediat Dept, I-21100 Varese, Italy

[3] Univ Geneva, Fac Med, Dept Pathol & Immunol, CH-1206 Geneva, Switzerland

[4] ASST Settelaghi, Hosp F Ponte, Pediatr Oncohaematol Day Hosp, I-21100 Varese, Italy

[5] Univ Naples Federico II, Dept Pharm, I-80131 Naples, Italy

[6] Univ Milano Bicocca, San Gerardo Hosp, Dept Pediat, Tettamanti Res Ctr, I-20900 Monza, Italy

[7] Univ Geneva, Dept Pathol & Immunol, Fac Med, CH-1206 Geneva, Switzerland

[8] Ludwig Inst Canc Res, Lausanne Branch, CH-1066 Epalinges, Switzerland

来源：

CELL REPORTS | 2022年 / 39卷 / 11期

基金：

瑞士国家科学基金会;

关键词：

INNATE LYMPHOID-CELLS; T-CELLS; PERIPHERAL-BLOOD; GENE-EXPRESSION; DISEASE; DIAGNOSIS; CHILDREN; ACTIVATION; GUIDELINES; INITIATION;

D O I：

10.1016/j.celrep.2022.110956

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Celiac disease (CD) is a multisystem disease in which different organs may be affected. We investigate whether circulating innate lymphoid cells (ILCs) contribute to the CD peripheral inflammatory status. We find that the CD cytokine profile is characterized by high concentrations of IL-12p40, IL-18, and IFN-gamma, paralleled by an expansion of ILC precursors (ILCPs). In the presence of the gliadin peptides p31-43 and p alpha-9, ILCPs from CD patients increase transglutaminase 2 (TG2) expression, produce IL-18 and IFN-gamma, and stimulate CD4(+) T lymphocytes. IFN-gamma is also produced upon stimulation with IL-12p40 and IL-18 and is inhibited by the addition of vitamin D. Low levels of blood vitamin D correlate with high IFN-gamma and ILCP presence and mark the CD population mostly affected by extraintestinal symptoms. Dietary vitamin D supplementation appears to be an interesting therapeutic approach to dampen ILCP-mediated IFN-gamma production.

引用

页数：18

共 66 条

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