Helper T Cells in Idiopathic Membranous Nephropathy

被引：34

作者：

Zhao, Qihan ^{[1
]}

Dai, Haoran ^{[2
]}

Liu, Xianli ^{[2
]}

Jiang, Hanxue ^{[1
]}

Liu, Wenbin ^{[3
]}

Feng, Zhendong ^{[1
,4
]}

Zhang, Na ^{[1
]}

Gao, Yu ^{[1
]}

Dong, Zhaocheng ^{[1
,3
]}

Zhou, Xiaoshan ^{[1
,3
]}

Du, Jieli ^{[1
,3
]}

Zhang, Naiqian ^{[1
,3
]}

Rui, Hongliang ^{[5
]}

Yuan, Li ^{[6
]}

Liu, Baoli ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China

[2] Beijing Tradit Chinese Med Hosp, Shunyi Branch, Beijing, Peoples R China

[3] Beijing Univ Chinese Med, Beijing, Peoples R China

[4] Pinggu Hosp, Beijing Chinese Med Hosp, Beijing, Peoples R China

[5] Capital Med Univ, Beijing Hosp Tradit Chinese Med, Beijing Inst Tradit Chinese Med, Beijing, Peoples R China

[6] Nantong Univ, Affiliated Hosp, Dept Nephrol, Nantong, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

基金：

中国国家自然科学基金;

关键词：

idiopathic membranous nephropathy (IMN); helper T cells (Th cells); autoimmune; antibodies; germinal center (GC); DISEASE-ACTIVITY; B-CELLS; RECEPTOR; PATHOGENESIS; RATIO; IGG4; ABNORMALITY; RESPONSES; PROMOTE; SUBSETS;

D O I：

10.3389/fimmu.2021.665629

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Idiopathic membranous nephropathy (IMN) is an autoimmune disease in which the immune system produces an antibody response to its own antigens due to impaired immune tolerance. Although antibodies are derived from plasma cells differentiated by B cells, the T-B cells also contribute a lot to the immune system. In particular, the subsets of helper T (Th) cells, including the dominant subsets such as Th2, Th17, and follicular helper T (Tfh) cells and the inferior subsets such as regulatory T (Treg) cells, shape the immune imbalance of IMN and promote the incidence and development of autoimmune responses. After reviewing the physiological knowledge of various subpopulations of Th cells and combining the existing studies on Th cells in IMN, the role model of Th cells in IMN was explained in this review. Finally, the existing clinical treatment regimens for IMN were reviewed, and the importance of the therapy for Th cells was highlighted.

引用

页数：15

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